Title:
TRIPEPTIDE PRODRUG COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2002000263
Kind Code:
A3
Abstract:
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.
Inventors:
BEBBINGTON CHRISTOPHER R (US)
DUBOIS VINCENT (BE)
GANGWAR SANJEEV (US)
LOBL THOMAS J (US)
NIEDER MATTHEW H (US)
PICKFORD LESLEY B (US)
TROUET ANDRE (BE)
YARRANTON GEOFFREY T (US)
DUBOIS VINCENT (BE)
GANGWAR SANJEEV (US)
LOBL THOMAS J (US)
NIEDER MATTHEW H (US)
PICKFORD LESLEY B (US)
TROUET ANDRE (BE)
YARRANTON GEOFFREY T (US)
Application Number:
PCT/US2001/040925
Publication Date:
August 15, 2002
Filing Date:
June 11, 2001
Export Citation:
Assignee:
CORIXA CORP (US)
BEBBINGTON CHRISTOPHER R (US)
DUBOIS VINCENT (BE)
GANGWAR SANJEEV (US)
LOBL THOMAS J (US)
NIEDER MATTHEW H (US)
PICKFORD LESLEY B (US)
TROUET ANDRE (BE)
YARRANTON GEOFFREY T (US)
BEBBINGTON CHRISTOPHER R (US)
DUBOIS VINCENT (BE)
GANGWAR SANJEEV (US)
LOBL THOMAS J (US)
NIEDER MATTHEW H (US)
PICKFORD LESLEY B (US)
TROUET ANDRE (BE)
YARRANTON GEOFFREY T (US)
International Classes:
A61K31/704; A61K47/48; A61P29/00; A61P31/00; A61P35/00; A61P43/00; C07K5/02; C07K5/08; C07K5/083; C07K5/087; A61K38/00; (IPC1-7): A61K47/48; A61K49/00; C07K5/08
Domestic Patent References:
| WO2000033888A2 | 2000-06-15 | |||
| WO1996005863A1 | 1996-02-29 |
Other References:
MASQUELIER ET AL: "Antitumor activity of daunorubicin linked to proteins: biological and antitumor properties of peptidic derivatives of daunorubicin used as intermediates", CHEMABS, XP002139800
MASQUELIER M ET AL: "AMINO ACID AND DIPEPTIDE DERIVATIVES OF DAUNORUBICIN. 1. SYNTHESIS,PHYSICOCHEMICAL PROPERTIES, AND LYSOSOMAL DIGESTION", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 23, no. 11, 1980, pages 1166 - 1170, XP000914522, ISSN: 0022-2623
MARRE DE A ET AL: "EVALUATION OF THE HYDROLYTIC AND ENZYMATIC STABILITY OF MACROMOLECULAR MITOMYCIN C DERIVATIVES", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 31, no. 1, 1994, pages 89 - 97, XP000456583, ISSN: 0168-3659
SUBR V: "POLYMERS CONTAINING ENZYMATICALLY DEGRADABLE BONDS. ÖXII. EFFECT OF SPACER STRUCTURE ON THE RATE OF RELEASE OF DAUNOMYCIN AND ADRIAMYCIN FROM POLY(N-(2-HYDROXYPROPYL)-METHACRYLAMIDE) COPOLYMER DRUG CARRIERS INVITRO AND ANTITUMOUR ACTIVITY MEASURED IN VIVO", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 18, no. 2, 1 February 1992 (1992-02-01), pages 123 - 132, XP000247009, ISSN: 0168-3659
MASQUELIER M ET AL: "AMINO ACID AND DIPEPTIDE DERIVATIVES OF DAUNORUBICIN. 1. SYNTHESIS,PHYSICOCHEMICAL PROPERTIES, AND LYSOSOMAL DIGESTION", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 23, no. 11, 1980, pages 1166 - 1170, XP000914522, ISSN: 0022-2623
MARRE DE A ET AL: "EVALUATION OF THE HYDROLYTIC AND ENZYMATIC STABILITY OF MACROMOLECULAR MITOMYCIN C DERIVATIVES", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 31, no. 1, 1994, pages 89 - 97, XP000456583, ISSN: 0168-3659
SUBR V: "POLYMERS CONTAINING ENZYMATICALLY DEGRADABLE BONDS. ÖXII. EFFECT OF SPACER STRUCTURE ON THE RATE OF RELEASE OF DAUNOMYCIN AND ADRIAMYCIN FROM POLY(N-(2-HYDROXYPROPYL)-METHACRYLAMIDE) COPOLYMER DRUG CARRIERS INVITRO AND ANTITUMOUR ACTIVITY MEASURED IN VIVO", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 18, no. 2, 1 February 1992 (1992-02-01), pages 123 - 132, XP000247009, ISSN: 0168-3659
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