Title:
TRIPHENYLAZOLE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/063147
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula (I) and useful as a pharmaceutical product, or a pharmaceutically acceptable salt thereof. The present invention further provides a pharmaceutical composition for the treatment or prevention of synucleinopathy.
Inventors:
YOSHINO HIROSHI (JP)
KOMODA TAICHI (JP)
ITO MASAHIKO (JP)
FUKUNAGA KOJI (JP)
KAWAHATA ICHIRO (JP)
KOMODA TAICHI (JP)
ITO MASAHIKO (JP)
FUKUNAGA KOJI (JP)
KAWAHATA ICHIRO (JP)
Application Number:
PCT/JP2023/034339
Publication Date:
March 28, 2024
Filing Date:
September 21, 2023
Export Citation:
Assignee:
SHIRATORI PHARMACEUTICAL CO LTD (JP)
UNIV TOHOKU (JP)
UNIV TOHOKU (JP)
International Classes:
C07D231/12; A61K31/415; A61K31/4196; A61P9/10; A61P17/02; A61P25/00; A61P25/02; A61P25/16; A61P25/28; C07D249/08; C12N15/12
Domestic Patent References:
| WO2017171053A1 | 2017-10-05 |
Other References:
YOKO BENIYAMA, KENJI MATSUNO, HIROYUKI MIYACHI: "Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, vol. 23, no. 6, 1 March 2013 (2013-03-01), pages 1662 - 1666, XP055083807, ISSN: 0960894X, DOI: 10.1016/j.bmcl.2013.01.054
SHINODA YASUHARU, WANG YIFEI, YAMAMOTO TETSUNORI, MIYACHI HIROYUKI, FUKUNAGA KOHJI: "Analysis of binding affinity and docking of novel fatty acid-binding protein (FABP) ligands", JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOCIETY , TOKYO, JP, vol. 143, no. 4, 1 August 2020 (2020-08-01), JP , pages 264 - 271, XP093148758, ISSN: 1347-8613, DOI: 10.1016/j.jphs.2020.05.005
TAN MARIA CARMEN; MATSUOKA SHIGERU; ANO HIKARU; ISHIDA HANAKO; HIROSE MIKA; SATO FUMINORI; SUGIYAMA SHIGERU; MURATA MICHIO: "Interaction kinetics of liposome-incorporated unsaturated fatty acids with fatty acid-binding protein 3 by surface plasmon resonance", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 22, no. 6, 13 February 2014 (2014-02-13), AMSTERDAM, NL, pages 1804 - 1808, XP028627442, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2014.02.001
SHINODA YASUHARU, WANG YIFEI, YAMAMOTO TETSUNORI, MIYACHI HIROYUKI, FUKUNAGA KOHJI: "Analysis of binding affinity and docking of novel fatty acid-binding protein (FABP) ligands", JOURNAL OF PHARMACOLOGICAL SCIENCES, JAPANESE PHARMACOLOGICAL SOCIETY , TOKYO, JP, vol. 143, no. 4, 1 August 2020 (2020-08-01), JP , pages 264 - 271, XP093148758, ISSN: 1347-8613, DOI: 10.1016/j.jphs.2020.05.005
TAN MARIA CARMEN; MATSUOKA SHIGERU; ANO HIKARU; ISHIDA HANAKO; HIROSE MIKA; SATO FUMINORI; SUGIYAMA SHIGERU; MURATA MICHIO: "Interaction kinetics of liposome-incorporated unsaturated fatty acids with fatty acid-binding protein 3 by surface plasmon resonance", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 22, no. 6, 13 February 2014 (2014-02-13), AMSTERDAM, NL, pages 1804 - 1808, XP028627442, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2014.02.001
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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