Title:
TRIPHENYLETHYLENE DERIVATIVE AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/1992/019585
Kind Code:
A1
Abstract:
A triphenylalkene derivative represented by general formula (1), a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical composition thereof having a tumor inhibitory action and an osteoporosis curing activity. In general formula (1) R�1? represents a group selected among those represented by formulae (2), (3) and (4); R�6? and R�7? represent each hydrogen, alkyl or cycloalkyl, or R�6? and R�7? together form a heterocyclic group with the adjacent nitrogen atom, provided that R�6? and R�7? should not be hydrogen atoms at the same time; R�8? represents hydrogen or alkylcarbonyl; R�2? represents alkyl or cycloalkyl; R�3? represents phenyl or 3,4-methylenedioxyphenyl, provided that when R�3? represents phenyl, the case where R�1? represents a group of formula (4) is excluded; R�4? represents hydrogen, hydroxyl, R�9?C(O)O-, R�10?OCH�2?O-, -OPO(OH)�2? or CH=NOR�11?; R�9? represents alkyl; R�10? represents alkyl or alkylcarbonyl; R�5? represents hydrogen or CH=NOR�11?; and R�11? represents hydrogen, alkyl or substituted alkyl.
Inventors:
KOUJI HIROYUKI (JP)
ANDO SATOSHI (JP)
ANDO SATOSHI (JP)
Application Number:
PCT/JP1992/000570
Publication Date:
November 12, 1992
Filing Date:
April 30, 1992
Export Citation:
Assignee:
ASAHI CHEMICAL IND (JP)
International Classes:
C07C217/18; C07C217/30; C07C217/34; C07C217/42; C07C219/06; C07C251/48; C07C251/60; C07D295/092; C07D317/50; C07D317/54; C07F9/12; C07F9/655; C07F9/6558; (IPC1-7): A61K31/135; A61K31/15; A61K31/36; A61K31/395; A61K31/66; C07C217/14; C07C217/28; C07C217/42; C07C219/06; C07C251/32; C07D295/08; C07D317/50; C07F9/12
Other References:
Mol. Pharmacol., Vol. 31, No. 5 (1987), COLIN K.W. etc., "Studies on the ligand specificity and potential identity of microsomal antiestrogen-binding sites", p. 541-551.
Biochem. J., Vol. 236, No. 3 (1986), COLIN K.W. etc., "Microsomal binding sites for antiestrogens in rat liver. Properties and detergent solubilization", p. 903-911.
See also references of EP 0589039A4
Biochem. J., Vol. 236, No. 3 (1986), COLIN K.W. etc., "Microsomal binding sites for antiestrogens in rat liver. Properties and detergent solubilization", p. 903-911.
See also references of EP 0589039A4
Attorney, Agent or Firm:
Hagino, Taira (14th Floor Toranomon-Mitsui Building, 8-1,
Kasumigaseki 3-chom, Chiyoda-ku Tokyo 100, JP)
Download PDF:
Previous Patent: NOVEL CYCLOHEXENE DERIVATIVE AND PRODUCTION THEREOF
Next Patent: PROCESS FOR THE PREPARATION OF 1-AMINO-4-BROMOANTHRAQUINONES
Next Patent: PROCESS FOR THE PREPARATION OF 1-AMINO-4-BROMOANTHRAQUINONES