TRIPLE-RESPONSE TYPE STARCH-BASED MICROGEL AND PREPARATION METHOD THEREFOR

WIPO Patent Application WO/2017/020237

A1

Disclosed are a triple-response type starch-based microgel and a preparation method therefor. In the present invention, a pH-sensitive C6-position fixed-point oxidized starch and a temperature-sensitive NIPAM (N-isopropylacrylamide) are mainly used as raw materials, and an inverse emulsion polymerization method is adopted to prepare a microgel with a semi-interpenetrating network of a C6-position fixed-point oxidized starch and PNIPAM, namely, the triple-response type starch-based microgel. The triple-response type starch-based microgel of the present invention is made up of spherical particles with a particle size of 15-25 μm, has three sensitivities to pH, temperature and ionic strength, and good biocompatibility and biodegradability, has a wide use in fields such as nutrient protection, drug controlled release, and protein separation and purification, and at the same time, has a simple and controllable preparation process, mild reaction conditions, and is suitable for large-scale production.

JIN ZHENGYU (CN)
TIAN YAOQI (CN)
ZHANG BAO (CN)
TAO HAN (CN)
WEI BENXI (CN)
HU XIUTING (CN)
WU CHUNSEN (CN)
XU XUEMING (CN)
YANG NA (CN)

PCT/CN2015/085997

February 09, 2017

August 04, 2015

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UNIV JIANGNAN (CN)

C08F2/32; C08B31/18; C08F220/54; C08F222/38

WO1999057158A1

1999-11-11

CN103709343A	2014-04-09
CN104403011A	2015-03-11
CN103992482A	2014-08-20
CN103755968A	2014-04-30
CN102311945A	2012-01-11

NANJING LI & FENG INTELLECTUAL PROPERTY AGENCY(SPECIAL GENERAL PARTNERSHIP) (CN)

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