Title:
TRIPRENYL PHENOL COMPOUND, PROCESS FOR PRODUCTION OF TRIPRENYL PHENOL COMPOUND, AND THROMBOLYSIS ENHANCER
Document Type and Number:
WIPO Patent Application WO/2007/111203
Kind Code:
A1
Abstract:
Disclosed is a triprenyl phenol compound having a thrombolysis-enhancing activity. Also disclosed is a process for production of the triprenyl phenol compound. The triprenyl phenol compound is represented by the general formula (II) or (III): (II) (III) wherein R1 represents an aromatic group having at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group as a substituent or a part of a substituent, or an aromatic group which has a secondary amino group and may have a nitrogen; R4 in the general formula (III) represents an aroamtic amino acid residue represented by the general formula (III-1) below; X represents –CHY-(CH3)2Z; and Y and Z independently represent –H or =OH or together form a single bond: (III-1) wherein R5 represents a hydroxyl group which may be absent; and n represents an integer of 0 or 1.
Inventors:
HASUMI KEIJI (JP)
KITANO YOSHIKAZU (JP)
OHISHI HIDEO (JP)
KOIDE HARUKI (JP)
HASEGAWA KEIKO (JP)
NARASAKI RITSUKO (JP)
KITANO YOSHIKAZU (JP)
OHISHI HIDEO (JP)
KOIDE HARUKI (JP)
HASEGAWA KEIKO (JP)
NARASAKI RITSUKO (JP)
Application Number:
PCT/JP2007/055749
Publication Date:
October 04, 2007
Filing Date:
March 20, 2007
Export Citation:
Assignee:
UNIV TOKYO AGRICULTURE & TECHNOLOGY TLO CO LTD (JP)
HASUMI KEIJI (JP)
KITANO YOSHIKAZU (JP)
OHISHI HIDEO (JP)
KOIDE HARUKI (JP)
HASEGAWA KEIKO (JP)
NARASAKI RITSUKO (JP)
HASUMI KEIJI (JP)
KITANO YOSHIKAZU (JP)
OHISHI HIDEO (JP)
KOIDE HARUKI (JP)
HASEGAWA KEIKO (JP)
NARASAKI RITSUKO (JP)
International Classes:
C12P17/18; A61K31/407; A61P7/02; A61P9/00; C07D491/052
Domestic Patent References:
| WO1998056940A1 | 1998-12-17 |
Foreign References:
| JP2002065288A | 2002-03-05 | |||
| JP2004224737A | 2004-08-12 | |||
| JP2004224738A | 2004-08-12 |
Other References:
XUEMIN XU ET AL.: "Stachybotrins A and B: Novel bioactive metabolites from a brackish water isolate of the fungus Stachybotrys sp", J. ORG. CHEM., vol. 57, 1992, pages 6700 - 6703, XP002914290
INOUE S. ET AL.: "Synthesis of tricyclic pyrano[2,3-e]isoindolin-3-ones as the core structure of stachybotrin A, B, and C", CHEM. COMMUN. (CAMB), no. 18, 2006, pages 1974 - 1976, XP003017798
See also references of EP 2000540A4
J. ORG. CHEM., vol. 57, 1992, pages 6700 - 6703
FEBS LETTER, vol. 418, 1997, pages 58 - 62
STACHYBOTRIN B, J. ORG. CHEM., vol. 57, 1992, pages 6700 - 6703
INOUE S. ET AL.: "Synthesis of tricyclic pyrano[2,3-e]isoindolin-3-ones as the core structure of stachybotrin A, B, and C", CHEM. COMMUN. (CAMB), no. 18, 2006, pages 1974 - 1976, XP003017798
See also references of EP 2000540A4
J. ORG. CHEM., vol. 57, 1992, pages 6700 - 6703
FEBS LETTER, vol. 418, 1997, pages 58 - 62
STACHYBOTRIN B, J. ORG. CHEM., vol. 57, 1992, pages 6700 - 6703
Attorney, Agent or Firm:
NAKAJIMA, Jun et al. (NAKAJIMA & KATO Seventh Floor,HK-Shinjuku Bldg.,3-17, Shinjuku 4-chom, Shinjuku-ku Tokyo 22, JP)
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