Title:
TRIPTOLIDE DERIVATIVES FOR MODULATION OF APOPTOSIS AND IMMUNOSUPPRESSION
Document Type and Number:
WIPO Patent Application WO2003101951
Kind Code:
A3
Abstract:
Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful as immunosuppressive, anti-inflammatory and anticancer agents.
Inventors:
DAI DONGCHENG (US)
MUSSER JOHN H (US)
LENNOX EDWIN S (US)
MUSSER JOHN H (US)
LENNOX EDWIN S (US)
Application Number:
PCT/US2003/017177
Publication Date:
May 06, 2004
Filing Date:
May 29, 2003
Export Citation:
Assignee:
PHARMAGENESIS INC (US)
DAI DONGCHENG (US)
MUSSER JOHN H (US)
LENNOX EDWIN S (US)
DAI DONGCHENG (US)
MUSSER JOHN H (US)
LENNOX EDWIN S (US)
International Classes:
A61K31/365; A61P35/00; A61P37/06; C07D493/22; (IPC1-7): A61K31/343; C07D407/14
Foreign References:
| US6569893B2 | 2003-05-27 |
Other References:
See also references of EP 1511478A4
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