Title:
TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES
Document Type and Number:
WIPO Patent Application WO2006009876
Kind Code:
A3
Abstract:
Compounds, compositions and methods are provided for modulating the activity of protein tyrosine phosphatases, including PTP-1B. In one embodiment, the compounds are N,N-dibenzylarylsulfonamides.
Inventors:
SEMPLE JOSEPH E (US)
RIDEOUT DARRYL (US)
NUTT RUTH F (US)
SHERNDEROVICH MARK (US)
WANG JING (US)
MYLVAGANAM SHANKARI (US)
WU FEIYUE (US)
TSAI CHUNG-YING (US)
YALAMOORI VENKATACHALAPATHI (US)
LOWETH COLIN J (US)
RIDEOUT DARRYL (US)
NUTT RUTH F (US)
SHERNDEROVICH MARK (US)
WANG JING (US)
MYLVAGANAM SHANKARI (US)
WU FEIYUE (US)
TSAI CHUNG-YING (US)
YALAMOORI VENKATACHALAPATHI (US)
LOWETH COLIN J (US)
Application Number:
PCT/US2005/021540
Publication Date:
March 30, 2006
Filing Date:
June 17, 2005
Export Citation:
Assignee:
CENGENT THERAPEUTICS INC (US)
SEMPLE JOSEPH E (US)
RIDEOUT DARRYL (US)
NUTT RUTH F (US)
SHERNDEROVICH MARK (US)
WANG JING (US)
MYLVAGANAM SHANKARI (US)
WU FEIYUE (US)
TSAI CHUNG-YING (US)
YALAMOORI VENKATACHALAPATHI (US)
LOWETH COLIN J (US)
SEMPLE JOSEPH E (US)
RIDEOUT DARRYL (US)
NUTT RUTH F (US)
SHERNDEROVICH MARK (US)
WANG JING (US)
MYLVAGANAM SHANKARI (US)
WU FEIYUE (US)
TSAI CHUNG-YING (US)
YALAMOORI VENKATACHALAPATHI (US)
LOWETH COLIN J (US)
International Classes:
(IPC1-7): A61K31/41; A61K31/18; C07D257/04; C07C303/00
Other References:
BRASELTON ET AL: "Gas Chromatographic and Mass Spectral Properties of Sulfonylurea N-Methyl-N'-perfluoroacyl Derivatives", ANALYTICAL CHEMISTRY, vol. 48, no. 9, 1976, pages 1386 - 1394
MORKVED ET AL: "Potential Acyl-transfer Agents. Reactions of N-acyl-2-pyridinecarboxamide with Nucleophiles", ACTA CHEMICA SCANDINAVICA B, vol. 36, 1982, pages 381 - 388
DATABASE CAS [online] YAMANE ET AL: "Reversible Thermal Recording Material Containing Aromatic Compound Color Developer", Database accession no. 133:112413
DATABASE CAS [online] RAJAGOPALAN S.: "Synthesis of N1, N4-diacylsulfanilamides", Database accession no. 39:3167
DATABASE CAS [online] RITTER ET AL: "Piperidine Derivative", Database accession no. 52:30289
MORKVED ET AL: "Potential Acyl-transfer Agents. Reactions of N-acyl-2-pyridinecarboxamide with Nucleophiles", ACTA CHEMICA SCANDINAVICA B, vol. 36, 1982, pages 381 - 388
DATABASE CAS [online] YAMANE ET AL: "Reversible Thermal Recording Material Containing Aromatic Compound Color Developer", Database accession no. 133:112413
DATABASE CAS [online] RAJAGOPALAN S.: "Synthesis of N1, N4-diacylsulfanilamides", Database accession no. 39:3167
DATABASE CAS [online] RITTER ET AL: "Piperidine Derivative", Database accession no. 52:30289
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