Title:
TRITERPENE SAPONIN ANALOGS HAVING ADJUVANT AND IMMUNOSTIMULATORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO1998052573
Kind Code:
A9
Abstract:
The present invention is directed to novel chemical compounds in which a lipophilic moiety such as a lipid, fatty acid, polyethylene glycol or terpene is covalently attached to a non-acylated or desacylated triterpene saponin via a carboxyl group present on the 3-O-glucuronic acid of the triterpene saponin. The attachment of a lipophile moiety to the 3-O-glucuronic acid of a saponin such as Quillaja desacylsaponin, lucyoside P, or saponin from Gypsophila, Saponaria and Acanthophyllum enhances their adjuvant effects on humoral and cell mediated immunity. Additionally, the attachment of a lipophile moiety to the 3-O-glucuronic acid residue of non- or des-acylsaponin yields a saponin analog that is easier to purify, less toxic, chemically more stable, and possesses equal or better adjuvant properties than the original saponin.
Inventors:
MARCIANI DANTE J (US)
Application Number:
PCT/US1998/010280
Publication Date:
April 01, 1999
Filing Date:
May 20, 1998
Export Citation:
Assignee:
GALENICA PHARMACEUTICALS INC (US)
MARCIANI DANTE J (US)
MARCIANI DANTE J (US)
International Classes:
A61K31/704; A61K36/00; A61K39/39; A61K47/48; A61K31/56; A61P37/04; A61P43/00; C07H15/256; C07J63/00; (IPC1-7): A61K31/56; A61K31/705; A61K35/78; A61K38/00
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