Title:
TRITERPENOID-CONTAINING PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/129249
Kind Code:
A1
Abstract:
The present invention relates to a novel use of a triterpenoid. In particular, the present invention provides a use of a compound of formula I, or an optical isomer thereof, or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof in the preparation of a pharmaceutical composition or a preparation for preventing and/or treating ocular diseases caused by crystalline lens lesions. A novel finding of the present invention is that the compound of formula I can prevent and/or treat ocular diseases caused by crystalline lens lesions, such as prevention and treatment of cataracts, is safe, has low toxicity and few side effects, and has remarkable therapeutic efficacy and development and application prospects.
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Inventors:
ZHENG QINYUAN (CN)
ZHU JINGJIE (CN)
QU JING (CN)
LUO YU (CN)
DING SHICHENG (CN)
QIN LIJUN (CN)
ZHOU XIANGYAN (CN)
SUN CHUANMIN (CN)
ZHAO FENQIN (CN)
ZHANG CUNQING (CN)
JI ZHONGWEI (CN)
GUO LI (CN)
ZHU JINGJIE (CN)
QU JING (CN)
LUO YU (CN)
DING SHICHENG (CN)
QIN LIJUN (CN)
ZHOU XIANGYAN (CN)
SUN CHUANMIN (CN)
ZHAO FENQIN (CN)
ZHANG CUNQING (CN)
JI ZHONGWEI (CN)
GUO LI (CN)
Application Number:
PCT/CN2018/125075
Publication Date:
July 04, 2019
Filing Date:
December 28, 2018
Export Citation:
Assignee:
SHANGHAI LANMU CHEMICALS CO LTD (CN)
ZHENG QINYUAN (CN)
ZHENG QINYUAN (CN)
International Classes:
A61K31/575; A61K31/58; A61K31/704; A61K36/07; A61P27/02; A61P27/10; A61P27/12; C07J9/00; C07J17/00
Domestic Patent References:
| WO2017136549A1 | 2017-08-10 |
Foreign References:
| CN107312053A | 2017-11-03 | |||
| KR20110101433A | 2011-09-16 |
Other References:
ZHAO, FENQIN ET AL.: "Triterpenoids from Inonotus Obliquus and Their Antitumor Activities", FITOTERAPIA, vol. 101, March 2015 (2015-03-01), pages 34 - 40, XP055622507, ISSN: 0367-326X, DOI: 10.1016/j.fitote.2014.12.005
DATABASE Registry 3 March 2017 (2017-03-03), retrieved from STN Database accession no. 2080382-78-9
ZHANG, XIANGHUA: "Experimental Study of Extracts from Inonotus Obliquus in the Treatment of STZ-Induced Diabetic Rats", MEDICINE & PUBLIC HEALTH, CHINA MASTER'S THESES FULL-TEXT DATABASE, 15 December 2017 (2017-12-15), pages E057 - 13 0
DATABASE Registry 3 March 2017 (2017-03-03), retrieved from STN Database accession no. 2080382-78-9
ZHANG, XIANGHUA: "Experimental Study of Extracts from Inonotus Obliquus in the Treatment of STZ-Induced Diabetic Rats", MEDICINE & PUBLIC HEALTH, CHINA MASTER'S THESES FULL-TEXT DATABASE, 15 December 2017 (2017-12-15), pages E057 - 13 0
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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