TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF

Title:

TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF

Document Type and Number:

WIPO Patent Application WO/2015/143652

Kind Code:

A8

Abstract:

The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula(I) which are tropomyosin-related kinase(Trk)family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF)receptor TrkA.

Inventors:

MITCHELL HELEN (US)
FRALEY MARK E (US)
COOKE ANDREW J (US)
STUMP CRAIG A (US)
BESHORE DOUGLAS C (US)
MCCOMAS CASEY C (US)
SCHIRRIPA KATHY (US)
MCWHERTER MELODY (US)
ZHANG XU-FANG (US)
MERCER SWATI P (US)
MOORE KEITH (US)
LIU CHUNGSING (CN)
MAO QINGHAU (CN)

Application Number:

PCT/CN2014/074143

Publication Date:

December 10, 2015

Filing Date:

March 26, 2014

Export Citation:

Click for automatic bibliography generation Help

Assignee:

MERCK SHARP & DOHME (US)
MITCHELL HELEN (US)
FRALEY MARK E (US)
COOKE ANDREW J (US)
STUMP CRAIG A (US)
BESHORE DOUGLAS C (US)
MCCOMAS CASEY C (US)
SCHIRRIPA KATHY (US)
MCWHERTER MELODY (US)
ZHANG XU-FANG (US)
MERCER SWATI P (US)
MOORE KEITH (US)
LIU CHUNGSING (CN)
MAO QINGHAU (CN)

International Classes:

C07D235/00; A61K31/16; A61P29/00; C07D263/52; C07D275/04; C07D277/60; C07D285/14; C07D291/08

Attorney, Agent or Firm:

LIU, SHEN & ASSOCIATES (Building 1 10 Caihefang Road, Haidian District, Beijing 0, CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: NETWORK FUNCTION VIRTUALIZATION-BASED CERTIFICATE CONFIGURATION METHOD, APPARATUS AND SYSTEM

Next Patent: TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF