TRNA SYNTHETASE INHIBITORS - HARVARD COLLEGE

Title:

TRNA SYNTHETASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2019/140265

Kind Code:

A1

Abstract:

Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis.

Inventors:

KAHNE DANIEL (US)
BAIDIN VADIM (US)

Application Number:

PCT/US2019/013305

Publication Date:

July 18, 2019

Filing Date:

January 11, 2019

Export Citation:

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Assignee:

HARVARD COLLEGE (US)

International Classes:

A61K31/69

Foreign References:

US20040224981A1	2004-11-11
US20120058133A1	2012-03-08

Other References:

DATABASE Pubchem 24 January 2012 (2012-01-24), XP055624222, Database accession no. 55193860

Attorney, Agent or Firm:

ABELLEIRA, Susan, M. et al. (US)

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