Title:
TROPANE COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2007/086554
Kind Code:
A1
Abstract:
It is known that a conventional anticholinergic agent for inhalation administration is antagonistic to muscarinic receptor in the airway smooth muscle and further migrates from airway to blood. As a result, it is concerned that there is a possibility that dysuria is aggravated by prostatic hyperplasia via blood. A long-acting inhaled anticholinergic agent with no possibility of such a side effect has been demanded. A compound represented by the general formula (I): (I) (wherein all symbols represent the same meaning as in the description), a salt thereof or a solvate thereof exerts an effect in a target region, is inactivated rapidly and is excellent in long-acting property, therefore, it is useful as a preventive and/or therapeutic agent for a muscarinic receptor-mediated disease with fewer side effects.
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Inventors:
NAKAI, Hisao (1-1, Sakurai 3-chome, Shimamoto-cho, Mishima-gu, Osaka 85, 6188585, JP)
中井 久郎 (〒85 大阪府三島郡島本町桜井三丁目１番１号 小野薬品工業株式会社内 Osaka, 6188585, JP)
NISHIYAMA, Toshihiko (1-1, Sakurai 3-chome, Shimamoto-cho, Mishima-gu, Osaka 85, 6188585, JP)
西山 敏彦 (〒85 大阪府三島郡島本町桜井三丁目１番１号 小野薬品工業株式会社内 Osaka, 6188585, JP)
中井 久郎 (〒85 大阪府三島郡島本町桜井三丁目１番１号 小野薬品工業株式会社内 Osaka, 6188585, JP)
NISHIYAMA, Toshihiko (1-1, Sakurai 3-chome, Shimamoto-cho, Mishima-gu, Osaka 85, 6188585, JP)
西山 敏彦 (〒85 大阪府三島郡島本町桜井三丁目１番１号 小野薬品工業株式会社内 Osaka, 6188585, JP)
Application Number:
JP2007/051367
Publication Date:
August 02, 2007
Filing Date:
January 29, 2007
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO., LTD. (1-5 Doshomachi 2-chome, Chuo-ku Osaka-sh, Osaka 26, 5418526, JP)
小野薬品工業株式会社 (〒26 大阪府大阪市中央区道修町二丁目１番５号 Osaka, 5418526, JP)
NAKAI, Hisao (1-1, Sakurai 3-chome, Shimamoto-cho, Mishima-gu, Osaka 85, 6188585, JP)
中井 久郎 (〒85 大阪府三島郡島本町桜井三丁目１番１号 小野薬品工業株式会社内 Osaka, 6188585, JP)
NISHIYAMA, Toshihiko (1-1, Sakurai 3-chome, Shimamoto-cho, Mishima-gu, Osaka 85, 6188585, JP)
小野薬品工業株式会社 (〒26 大阪府大阪市中央区道修町二丁目１番５号 Osaka, 5418526, JP)
NAKAI, Hisao (1-1, Sakurai 3-chome, Shimamoto-cho, Mishima-gu, Osaka 85, 6188585, JP)
中井 久郎 (〒85 大阪府三島郡島本町桜井三丁目１番１号 小野薬品工業株式会社内 Osaka, 6188585, JP)
NISHIYAMA, Toshihiko (1-1, Sakurai 3-chome, Shimamoto-cho, Mishima-gu, Osaka 85, 6188585, JP)
International Classes:
C07D451/10; A61K31/537; A61P11/00; A61P11/06; A61P43/00
Attorney, Agent or Firm:
IWATANI, Ryo (ORIX Dojima Bldg. 3F, 1-31 Dojima 2-chome, Kita-k, Osaka-shi Osaka 03, 5300003, JP)
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