Title:
TRPA1-ACTIVATING COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2014/129238
Kind Code:
A1
Abstract:
[Problem] To find a novel TRPA1-activating component and to provide a use of the TRPA1-activating component.
[Solution] A TRPA1-activating composition of the present invention contains, as active ingredient(s), an acrylic acid and/or an unsaturated aldehyde which has 4-12 carbon atoms and a main chain that has a double bond at least at the 2-position or at the 4-position. In this connection, in cases where a double bond is only at the 2-position, the main chain has 4-9 carbon atoms, while in cases where a double bond is only at the 4-position, the main chain has 9-12 carbon atoms. The present invention also provides a functional food and a pharmaceutical product, each of which contains this composition.
Inventors:
HIRA TOHRU (JP)
HARA HIROSHI (JP)
NISHIYAMA CHIGUSA (JP)
YAMASHITA TAKATOSHI (JP)
IMAGI JUN (JP)
HARA HIROSHI (JP)
NISHIYAMA CHIGUSA (JP)
YAMASHITA TAKATOSHI (JP)
IMAGI JUN (JP)
Application Number:
PCT/JP2014/050763
Publication Date:
August 28, 2014
Filing Date:
January 17, 2014
Export Citation:
Assignee:
J OIL MILLS INC (JP)
International Classes:
A61K31/19; A23L33/20; A61K8/33; A61K8/36; A61K31/11; A61P1/04; A61P1/10; A61P3/04; A61P3/06; A61P9/10; A61P9/12; A61P17/00; A61P43/00; A61Q7/02; A61Q19/00
Foreign References:
| US20090264376A1 | 2009-10-22 | |||
| JP2004018431A | 2004-01-22 | |||
| JP2012034662A | 2012-02-23 | |||
| US20130315843A1 | 2013-11-28 | |||
| JP2007325561A | 2007-12-20 |
Other References:
LINDSEY,M. ET AL.: "Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines", NATURE, vol. 445, 2007, pages 541 - 545, XP009149873, DOI: doi:10.1038/nature05544
MARCELLO,T. ET AL.: "4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1", PNAS, vol. 104, no. 33, 2007, pages 13519 - 13524
UTAKO YANO: "Umeboshi no Tokuchoko Seibun ni Tsuite", KORYO, vol. 253, 2012, pages 37 - 43
LAURA,S. ET AL.: "TRPA1 is activated by direct addition of cysteine residues to the N- hydroxysuccinyl esters of acrylic and cinnamic acids", PHARMACOLOGICAL RESEARCH, vol. 63, 2011, pages 30 - 36, XP028151220, DOI: doi:10.1016/j.phrs.2010.11.004
MARCELLO,T. ET AL.: "4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1", PNAS, vol. 104, no. 33, 2007, pages 13519 - 13524
UTAKO YANO: "Umeboshi no Tokuchoko Seibun ni Tsuite", KORYO, vol. 253, 2012, pages 37 - 43
LAURA,S. ET AL.: "TRPA1 is activated by direct addition of cysteine residues to the N- hydroxysuccinyl esters of acrylic and cinnamic acids", PHARMACOLOGICAL RESEARCH, vol. 63, 2011, pages 30 - 36, XP028151220, DOI: doi:10.1016/j.phrs.2010.11.004
Attorney, Agent or Firm:
NAKAJIMA SHINSUKE (JP)
Shinsuke Nakajima (JP)
Shinsuke Nakajima (JP)
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