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Title:
TRYCICLIC OR TETRACYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO/1986/001203
Kind Code:
A1
Abstract:
Compounds represented by general formula (I) (wherein A represents alkylene, Y-Z represents formula (II), -CH=CH-, -CH2CH2- or formula (III), R1 and R2 each represents a substituent, R3 represents hydrogen, alkyl or alkoxy, R4 represents phenyl, phenylalkyl, phenylalkenyl, diphenylmethyl, naphthyl, thiazolyl, optionally substituted pyridyl, optionally substituted pyrimidinyl, quinolyl, benzoylalkyl, benzoyl, furoyl, thenoyl, phenyloxycarbonyl, phenyloxysulfonyl or phenylsulfonyl, a represents 2 or 3, b and c each represents 1 or 2, and d represents an integer of 0 to 2, provided that the phenyl, phenyl moiety or naphthyl moiety may be substituted) and salts thereof, processess for their preparation, and medicinal compositions containing them. These compounds show a strong calcium-antagonistic effect, and are therefore useful for prophylaxis and treatment of hypertension and/or ischemic heart diseases.

Inventors:
Uno
Hitoshi, Kurokawa
Mikio, Sato
Fuminori, Hatano
Naonobu
Application Number:
PCT/JP1985/000445
Publication Date:
February 27, 1986
Filing Date:
August 09, 1985
Export Citation:
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Assignee:
Dainippon
Pharmaceutical
CO., LTD.
Uno, Hitoshi
Kurokawa, Mikio
Sato, Fuminori
Hatano, Naonobu
International Classes:
C07D311/88; A61K31/00; A61K31/435; A61K31/495; A61K31/55; A61P3/00; A61P9/00; A61P9/10; A61P9/12; C07D213/74; C07D215/38; C07D219/10; C07D239/42; C07D243/00; C07D277/38; C07D295/14; C07D295/15; C07D313/12; C07D335/18; C07D337/00; C07D337/12; C07D401/04; C07D409/12; (IPC1-7): C07D213/74; A61K31/495; A61K31/505; A61K31/55; C07D215/38; C07D239/42; C07D295/14; C07D337/12; C07D401/04; C07D409/12
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