TSP1 INHIBITOR - DAIICHI SANKYO CO LTD

Title:

TSP1 INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2023/136342

Kind Code:

A1

Abstract:

The present invention provides a cyclic peptide represented by formula (I) or a pharmaceutically acceptable salt thereof. [In the formula, A is selected from ring-forming groups A1-A5; Xaa1 is a residue of an aromatic amino acid; Xaa2 is a residue of an aliphatic amino acid, a basic amino acid, or an aromatic amino acid; Xaa3 and Xaa8 are independently selected and are each a structure in which a bond is formed between thiol groups of Xaa8 and Xaa3 in a residue of an amino acid represented by formula (III) or (III'); Xaa4 is a residue of a neutral amino acid; Xaa5 is a residue of a basic amino acid; Xaa6 is a residue of an acidic amino acid or a neutral amino acid; Xaa7 is a residue of an aromatic amino acid; Xaa9 is a residue of a basic amino acid, an aliphatic amino acid, or an aromatic amino acid; Xaa10 is a residue of an aromatic amino acid; and Xaa11 is a residue of an aliphatic amino acid.]

Inventors:

NOGAMI KAGAYAKI (JP)
YAMAGUCHI TAKAHIRO (JP)
FURUKAWA AKIHIRO (JP)
SAITO HIRONAO (JP)
ISHIGAI YUTAKA (JP)

Application Number:

PCT/JP2023/000979

Publication Date:

July 20, 2023

Filing Date:

January 16, 2023

Export Citation:

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Assignee:

DAIICHI SANKYO CO LTD (JP)
PEPTIDREAM INC (JP)

International Classes:

C07K7/08; A61K38/10; A61K38/12; A61K47/60; A61K47/61; A61K47/68; A61P9/10; A61P43/00; C07K14/765; C07K16/00; C07K19/00; C12N15/13

Domestic Patent References:

WO2018052002A1	2018-03-22
WO2018003983A1	2018-01-04

Foreign References:

JPH10504802A	1998-05-12
US20040102364A1	2004-05-27