Title:
TUBULAR EPITHELIAL PROGENITOR CELLS
Document Type and Number:
WIPO Patent Application WO/2013/047529
Kind Code:
A1
Abstract:
[Problem] To provide tubular epithelial progenitor cells and a process for producing same. [Solution] Tubular epithelial progenitor cells can be produced by carrying out a method that includes a culture step to obtain partially differentiated cells produced by culturing pluripotent stem cells, and an isolation step to isolate cells that express KSP-cadherin from these partially differentiated cells.
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Inventors:
MORIZANE RYUJI (JP)
MONKAWA TOSHIAKI (JP)
ITO HIROSHI (JP)
MONKAWA TOSHIAKI (JP)
ITO HIROSHI (JP)
Application Number:
PCT/JP2012/074577
Publication Date:
April 04, 2013
Filing Date:
September 25, 2012
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
C12N5/0735; A61K35/12; A61K35/22; A61L27/00; A61P13/12; C12N5/077; C12N5/10
Other References:
HISHIKAWA K. ET AL.: "Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 328, no. 1, 4 March 2005 (2005-03-04), pages 288 - 291, XP004723771
VIGNEAU C. ET AL.: "Mouse Embryonic Stem Cell- Derived Embryoid Bodies Generate Progenitors That Integrate Long Term into Renal Proximal Tubules In Vivo.", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 18, 2007, pages 1709 - 1720, XP055064555
RYUJI MORIZANE ET AL.: "Mouse ES Saibo o Mochiita Jin Kosei Saibo eno Bunka Yudo", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 51, no. 3, 2009, pages 309
MORIZANE R. ET AL.: "Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 390, no. 4, 25 December 2009 (2009-12-25), pages 1334 - 1339, XP008152385
BATCHELDER C.A. ET AL.: "Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors.", DIFFERENTIATION, vol. 78, no. 1, 1 July 2009 (2009-07-01), pages 45 - 56, XP026251689
THEDIECK C. ET AL.: "Expression of Ksp-cadherin during kidney development and in renal cell carcinoma.", BRITISH JOURNAL OF CANCER, vol. 92, 2005, pages 2010 - 2017, XP055064559
MUGFORD J.W. ET AL.: "Osrl expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osrl-dependent nephron progenitor compartment within the mammalian kidney.", DEVELOPMENTAL BIOLOGY, vol. 324, 2008, pages 88 - 98
TENA J.J. ET AL.: "Odd-skipped genes encode repressors that control kidney development.", DEVELOPMENTAL BIOLOGY, vol. 301, no. 2, 13 January 2007 (2007-01-13), pages 518 - 531, XP005734626
RYUJI MORIZANE ET AL.: "Mouse ES Saibo o Mochiita Jin Kosei Saibo eno Bunka Yudo", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 50, no. 3, 2008, pages 392
VIGNEAU C. ET AL.: "Mouse Embryonic Stem Cell- Derived Embryoid Bodies Generate Progenitors That Integrate Long Term into Renal Proximal Tubules In Vivo.", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 18, 2007, pages 1709 - 1720, XP055064555
RYUJI MORIZANE ET AL.: "Mouse ES Saibo o Mochiita Jin Kosei Saibo eno Bunka Yudo", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 51, no. 3, 2009, pages 309
MORIZANE R. ET AL.: "Differentiation of murine embryonic stem and induced pluripotent stem cells to renal lineage in vitro.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 390, no. 4, 25 December 2009 (2009-12-25), pages 1334 - 1339, XP008152385
BATCHELDER C.A. ET AL.: "Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors.", DIFFERENTIATION, vol. 78, no. 1, 1 July 2009 (2009-07-01), pages 45 - 56, XP026251689
THEDIECK C. ET AL.: "Expression of Ksp-cadherin during kidney development and in renal cell carcinoma.", BRITISH JOURNAL OF CANCER, vol. 92, 2005, pages 2010 - 2017, XP055064559
MUGFORD J.W. ET AL.: "Osrl expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osrl-dependent nephron progenitor compartment within the mammalian kidney.", DEVELOPMENTAL BIOLOGY, vol. 324, 2008, pages 88 - 98
TENA J.J. ET AL.: "Odd-skipped genes encode repressors that control kidney development.", DEVELOPMENTAL BIOLOGY, vol. 301, no. 2, 13 January 2007 (2007-01-13), pages 518 - 531, XP005734626
RYUJI MORIZANE ET AL.: "Mouse ES Saibo o Mochiita Jin Kosei Saibo eno Bunka Yudo", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 50, no. 3, 2008, pages 392
Attorney, Agent or Firm:
ISSHIKI & CO. (JP)
All international patent business corporation (JP)
All international patent business corporation (JP)
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