Title:
TUBULYSINS AND PROTEIN-TUBULYSIN CONJUGATES
Document Type and Number:
WIPO Patent Application WO/2020/132658
Kind Code:
A3
Abstract:
Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof.
Inventors:
HAN AMY (US)
KELLY MARCUS (US)
OLSON WILLIAM (US)
KELLY MARCUS (US)
OLSON WILLIAM (US)
Application Number:
PCT/US2019/068185
Publication Date:
August 13, 2020
Filing Date:
December 20, 2019
Export Citation:
Assignee:
REGENERON PHARMA (US)
International Classes:
C07K5/02; A61K47/68; A61P35/00; C07K5/078
Domestic Patent References:
| WO2008138561A1 | 2008-11-20 | |||
| WO2014126836A1 | 2014-08-21 | |||
| WO2015113760A1 | 2015-08-06 | |||
| WO2018058001A1 | 2018-03-29 | |||
| WO2015026907A1 | 2015-02-26 | |||
| WO2016077260A1 | 2016-05-19 | |||
| WO2009055562A1 | 2009-04-30 |
Foreign References:
| US20180125992A1 | 2018-05-10 |
Other References:
MONICA SANI ET AL: "Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline", CHEMISTRY - A EUROPEAN JOURNAL, vol. 23, no. 24, 27 April 2017 (2017-04-27), DE, pages 5842 - 5850, XP055518907, ISSN: 0947-6539, DOI: 10.1002/chem.201700874
CHAI Y ET AL: "Discovery of 23 Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 17, no. 3, 26 March 2010 (2010-03-26), pages 296 - 309, XP026984443, ISSN: 1074-5521, [retrieved on 20100324]
YING XU ET AL: "A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug Conjugates", INT. J. MOL. SCI., vol. 18, no. 11, 1 November 2017 (2017-11-01), pages 2284, XP055709824, ISSN: 1661-6596, DOI: 10.3390/ijms18112284
CHAI Y ET AL: "Discovery of 23 Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 17, no. 3, 26 March 2010 (2010-03-26), pages 296 - 309, XP026984443, ISSN: 1074-5521, [retrieved on 20100324]
YING XU ET AL: "A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug Conjugates", INT. J. MOL. SCI., vol. 18, no. 11, 1 November 2017 (2017-11-01), pages 2284, XP055709824, ISSN: 1661-6596, DOI: 10.3390/ijms18112284
Attorney, Agent or Firm:
NOSON, Kevin et al. (US)
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