Title:
TUMOR ANGIOGENESIS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2011/115271
Kind Code:
A1
Abstract:
Provided is an antitumor agent, or more specifically, an angiogenesis inhibitor, that contains as an active ingredient a substance which suppresses the expression or function of ENAH. Specifically, the angiogenesis inhibitor contains: an antisense nucleic acid, a ribozyme, or a nucleic acid having RNAi activity for the transcription product of the gene that encodes ENAH; or an antibody, or the like, that binds to ENAH. Also provided is a method for screening angiogenesis inhibitors, characterized in that the genes that encode ENAH, or compounds that reduce the level of expression of ENAH or the function of ENAH, are selected.
Inventors:
HIDA KYOKO
HIDA YASUHIRO
OHGA NORITAKA
OTSUBO TSUGUTERU (JP)
IWASAKI TSUYOSHI (JP)
KAI TOSHIHIRO (JP)
SATO HIDESHI (JP)
HIDA YASUHIRO
OHGA NORITAKA
OTSUBO TSUGUTERU (JP)
IWASAKI TSUYOSHI (JP)
KAI TOSHIHIRO (JP)
SATO HIDESHI (JP)
Application Number:
PCT/JP2011/056639
Publication Date:
September 22, 2011
Filing Date:
March 18, 2011
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
HIDA KYOKO
HIDA YASUHIRO
OHGA NORITAKA
OTSUBO TSUGUTERU (JP)
IWASAKI TSUYOSHI (JP)
KAI TOSHIHIRO (JP)
SATO HIDESHI (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
HIDA KYOKO
HIDA YASUHIRO
OHGA NORITAKA
OTSUBO TSUGUTERU (JP)
IWASAKI TSUYOSHI (JP)
KAI TOSHIHIRO (JP)
SATO HIDESHI (JP)
International Classes:
C12N15/00; A61K31/7088; A61K31/713; A61K39/395; A61K45/00; A61K48/00; A61P35/00; C07K16/18; C12N15/09; C12N15/113; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50
Domestic Patent References:
| WO2009150494A1 | 2009-12-17 |
Other References:
GURZU, SIMONA ET AL.: "The expression of cytoskeleton regulatory protein Mena in colorectal lesions.", ROM. J. MORPHOL. EMBRYOL., vol. 49, no. 3, 2008, pages 345 - 349
PINO, MARIA S ET AL.: "Human Mena+lla isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines.", CLIN. CANCER. RES., vol. 14, no. 15, 2008, pages 4943 - 4950
DI MODUGNO, FRANCESCA ET AL.: "Molecular cloning of hMena (ENAH) and its splice variant hMena+ lla: epidermal growth factor increases their expression and stimulates hMena+lla phosphorylation in breast cancer cell lines.", CANCER RES., vol. 67, no. 6, 2007, pages 2657 - 2665
URBANELLI, LORENA ET AL.: "Characterization of human Enah gene.", BIOCHIM. BIOPHYS. ACTA, vol. 1759, 2006, pages 99 - 107
PHILIPPAR, ULRIKE ET AL.: "A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.", DEV. CELL., vol. 15, 2008, pages 813 - 828
GOSWAMI, SUMANTA ET AL.: "Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.", CLIN. EXP. METASTASIS., vol. 26, no. 2, 2009, pages 153 - 159
HIGASHI, MORIHIRO ET AL.: "Human Mena associates with Racl small GTPase in glioblastoma cell lines. abst. e4765", PLOS ONE., vol. 4, no. 3, 2009, pages 1 - 13
PINO, MARIA S ET AL.: "Human Mena+lla isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines.", CLIN. CANCER. RES., vol. 14, no. 15, 2008, pages 4943 - 4950
DI MODUGNO, FRANCESCA ET AL.: "Molecular cloning of hMena (ENAH) and its splice variant hMena+ lla: epidermal growth factor increases their expression and stimulates hMena+lla phosphorylation in breast cancer cell lines.", CANCER RES., vol. 67, no. 6, 2007, pages 2657 - 2665
URBANELLI, LORENA ET AL.: "Characterization of human Enah gene.", BIOCHIM. BIOPHYS. ACTA, vol. 1759, 2006, pages 99 - 107
PHILIPPAR, ULRIKE ET AL.: "A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.", DEV. CELL., vol. 15, 2008, pages 813 - 828
GOSWAMI, SUMANTA ET AL.: "Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.", CLIN. EXP. METASTASIS., vol. 26, no. 2, 2009, pages 153 - 159
HIGASHI, MORIHIRO ET AL.: "Human Mena associates with Racl small GTPase in glioblastoma cell lines. abst. e4765", PLOS ONE., vol. 4, no. 3, 2009, pages 1 - 13
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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