Title:
TUMOR MOLECULAR MARKER CIRCBIRC6 AND INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/169710
Kind Code:
A1
Abstract:
Provided are a tumor molecular marker circBIRC6 and an inhibitor and the use thereof. The expression level of the circBIRC6 gene in gastric cancer patients is significantly upregulated. By using the circBIRC6 inhibitor, the circBIRC6 in human gastric cancer cells is knocked down at the cellular level, such that the proliferation, invasion and migration abilities of gastric cancer cells are decreased, and the circBIRC6 inhibitor may also be suitable for a variety of cancers with abnormal expression of circBIRC6.
More Like This:
Inventors:
HUANG JIANFEI (CN)
LI JIEYING (CN)
LI JIEYING (CN)
Application Number:
PCT/CN2018/084506
Publication Date:
September 12, 2019
Filing Date:
April 25, 2018
Export Citation:
Assignee:
AFFILIATED HOSPITAL OF NANTONG UNIV (CN)
International Classes:
C12Q1/68; C12N15/113
Foreign References:
| CN107177669A | 2017-09-19 |
Other References:
JIANG JINWEI ET AL: "Expressions of BIRC6 in Hepatocellular Carcinoma and Their Effects on Apoptosis of Hepatocellular Carcinoma Cell", JOURNAL OF CHONGQING MEDICAL UNIVERSITY, vol. 38, no. 9, 30 September 2013 (2013-09-30), pages 1022 - 1026, ISSN: 0253-3626
YU , CHUNYING ET AL.: "The Circular RNA CircBIRC6 Participates in the Molecular Circuitry Controlling Human Pluripotency", NATURE COMMUNICATIONS, vol. 8, no. 1149, 27 October 2017 (2017-10-27), XP055637525, ISSN: 2041-1723
YU , CHUNYING ET AL.: "The Circular RNA CircBIRC6 Participates in the Molecular Circuitry Controlling Human Pluripotency", NATURE COMMUNICATIONS, vol. 8, no. 1149, 27 October 2017 (2017-10-27), XP055637525, ISSN: 2041-1723
Attorney, Agent or Firm:
KEYCOM PARTNERS, P.C. (CN)
Download PDF: