Title:
TUMOR VACCINE
Document Type and Number:
WIPO Patent Application WO2002060476
Kind Code:
A3
Abstract:
The invention relates to a vaccine and to the production thereof for the treatment of patients suffering from defined tumor diseases. The inventive vaccine consists of tumor cells that were transfected ex vivo with expression constructs that code for certain cytokines. Immunostimulating oligodeoxyribonucleotides are used as the adjuvants.
Inventors:
WITTIG BURGHARDT (DE)
SCHMIDT-WOLF INGO (DE)
DORBIC TOMISLAV (DE)
SCHMIDT-WOLF INGO (DE)
DORBIC TOMISLAV (DE)
Application Number:
PCT/DE2002/000380
Publication Date:
January 23, 2003
Filing Date:
January 30, 2002
Export Citation:
Assignee:
MOLOGEN FORSCHUNGS ENTWICKLUNG (DE)
WITTIG BURGHARDT (DE)
SCHMIDT-WOLF INGO (DE)
DORBIC TOMISLAV (DE)
WITTIG BURGHARDT (DE)
SCHMIDT-WOLF INGO (DE)
DORBIC TOMISLAV (DE)
International Classes:
A61K39/00; A61P35/00; (IPC1-7): A61K39/00; A61K39/39; A61P35/00
Domestic Patent References:
| WO2000072686A1 | 2000-12-07 | |||
| WO1994004196A1 | 1994-03-03 | |||
| WO1998018810A1 | 1998-05-07 | |||
| WO2001007055A1 | 2001-02-01 |
Foreign References:
| US6051428A | 2000-04-18 |
Other References:
MOELLER P ET AL: "Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: A clinical phase I study.", BRITISH JOURNAL OF CANCER, vol. 77, no. 11, June 1998 (1998-06-01), pages 1907 - 1916, XP002211538, ISSN: 0007-0920
SCHAKOWSKI FRANK ET AL: "A novel type of minimal size non-viral vector with improved safety properties for clinical trials and enhanced transgene expression: First results.", BLOOD, vol. 96, no. 11 Part 2, 16 November 2000 (2000-11-16), 42nd Annual Meeting of the American Society of Hematology;San Francisco, California, USA; December 01-05, 2000, pages 383b, XP001074277, ISSN: 0006-4971
WITTIG B ET AL: "Therapeutic vaccination against metastatic carcinoma by expression-modulated and immunomodified autologous tumor cells: a first clinical phase I/II trial.", HUMAN GENE THERAPY. UNITED STATES 10 FEB 2001, vol. 12, no. 3, 10 February 2001 (2001-02-10), pages 267 - 278, XP002211539, ISSN: 1043-0342
SCHAKOWSKI FRANK ET AL: "A novel type of minimal size non-viral vector with improved safety properties for clinical trials and enhanced transgene expression: First results.", BLOOD, vol. 96, no. 11 Part 2, 16 November 2000 (2000-11-16), 42nd Annual Meeting of the American Society of Hematology;San Francisco, California, USA; December 01-05, 2000, pages 383b, XP001074277, ISSN: 0006-4971
WITTIG B ET AL: "Therapeutic vaccination against metastatic carcinoma by expression-modulated and immunomodified autologous tumor cells: a first clinical phase I/II trial.", HUMAN GENE THERAPY. UNITED STATES 10 FEB 2001, vol. 12, no. 3, 10 February 2001 (2001-02-10), pages 267 - 278, XP002211539, ISSN: 1043-0342
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