Title:
TUNED SYNTHETIC DENDRIMER CALIBRANTS FOR MASS SPECTROMETRY
Document Type and Number:
WIPO Patent Application WO/2010/091109
Kind Code:
A3
Abstract:
Provided are monodisperse synthetic dendrimer calibrants for mass spectrometry. The calibrants are distinguished by their relative ease and rapidity of synthesis, comparatively low cost, long shelf life, high purity, and amenability to batch synthesis as mixtures. The latter characteristic enables parallel preparation of higher molecular weight compounds displaying useful distributions of discrete molecular weights, thereby providing multi-point mass spectrometry calibration standards. Methods of making and using said calibrants are also provided.
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Inventors:
GRAYSON SCOTT M (US)
Application Number:
PCT/US2010/023087
Publication Date:
April 07, 2011
Filing Date:
February 03, 2010
Export Citation:
Assignee:
UNIV TULANE (US)
GRAYSON SCOTT M (US)
GRAYSON SCOTT M (US)
International Classes:
C07D319/06; G01N30/72
Foreign References:
| US20050112635A1 | 2005-05-26 |
Other References:
CHIKH L. ET AL.: "Polydispersity of Hyperbranched Polyesters Based on 2,2-Bis (hydroxymethyl)propanoic Acid: SEC/MALDI-TOF MS and 13C NMR/Kinetic-Recursiv e probability Analysis.", MACROMOLECULES, vol. 41, no. 23, 2008, pages 9044 - 9050, XP055029548
IHRE H. ET AL.: "Fast and Convenient Divergent Synthesis of Aliphatic Ester D endrimers by Anhydride Coupling.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 123, no. 25, 2001, pages 5908 - 5917, XP002638672
WURSCH A. ET AL.: "Dendritic-Linear AxBx Block Copolymers Prepared via Controlled Ring-Opening Polymerization of Lactones from Orthogonally Protected Multifunctional Initiators.", MACROMOLECULES, vol. 34, no. 19, 2001, pages 6601 - 6615, XP055075081
See also references of EP 2393798A4
IHRE H. ET AL.: "Fast and Convenient Divergent Synthesis of Aliphatic Ester D endrimers by Anhydride Coupling.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 123, no. 25, 2001, pages 5908 - 5917, XP002638672
WURSCH A. ET AL.: "Dendritic-Linear AxBx Block Copolymers Prepared via Controlled Ring-Opening Polymerization of Lactones from Orthogonally Protected Multifunctional Initiators.", MACROMOLECULES, vol. 34, no. 19, 2001, pages 6601 - 6615, XP055075081
See also references of EP 2393798A4
Attorney, Agent or Firm:
MOORE, Chester, G. (Donelson Bearman, Caldwell & Berkowitz, P.C.,3 Sanctuary Boulevard,Suite 20, Mandeville LA, US)
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