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Title:
TUNING THE PROPERTIES OF CONJUGATED POLYELECTROLYTES AND APPLICATION IN A BIOSENSOR PLATFORM
Document Type and Number:
WIPO Patent Application WO2002079268
Kind Code:
A3
Abstract:
The present invention provides a method of detecting a biological agent including contacting a sample with a sensor including a polymer system capable of having an alterable measurable property from the group of luminescence, anisotropy, redox potential and uv/vis absorption, the polymer system including an ionic conjugated polymer and an electronically inert polyelectrolyte having a biological agent recognition element bound thereto, the electronically inert polyelectrolyte adapted for undergoing a conformational structural change upon exposure to a biological agent having affinity for binding to the recognition element bound to the electronically inert polyelectrolyte, and detecting the detectable change in the alterable measurable property. A chemical moiety being the reaction product of (i) a polyelectrolyte monomer and (ii) a biological agent recognition element-substituted polyelectrolyte monomer is also provided.

Inventors:
CHEN LIAOHAI
Application Number:
US0208741W
Publication Date:
August 07, 2003
Filing Date:
March 21, 2002
Export Citation:
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Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
International Classes:
G01N33/543; (IPC1-7): C07K1/13; C07K17/08; C12N9/96; G01N33/533; G01N33/545; G01N33/547
Domestic Patent References:
WO2000066790A12000-11-09
Foreign References:
US5866322A1999-02-02
US6251866B12001-06-26
US5670381A1997-09-23
US5166320A1992-11-24
US6312727B12001-11-06
Other References:
XIA J. ET AL.: 'Electrophoretic and quasi-elastic light scattering of soluble protein-polyelectrolyte complexes' JOURNAL OF PHYSICAL CHEMISTRY vol. 97, 1993, pages 4528 - 4534, XP002963367
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