Title:
TYPE II ANTI-CD20 ANTIBODY FOR USE IN ORGAN TRANSPLANTATION
Document Type and Number:
WIPO Patent Application WO/2017/004091
Kind Code:
A8
Abstract:
The present disclosure provides, inter alia, methods for treating an individual in need of an organ transplantation, such as a renal transplantation, by administering to the individual an effective amount of a type II anti-CD20 antibody before, concurrently with, and/or after the transplantation. In some embodiments, the methods may reduce alloantibodies, Panel Reactive Antibodies (PRA), and/or risk of graft rejection. In some embodiments, the methods further comprise administering to the individual a dose of intravenous immunoglobulin (IVIG) before the transplantation.
Inventors:
BRUNETTA PAUL (US)
BORIE DOMINIQUE (US)
BORIE DOMINIQUE (US)
Application Number:
PCT/US2016/039905
Publication Date:
January 11, 2018
Filing Date:
June 28, 2016
Export Citation:
Assignee:
GENENTECH INC (US)
HOFFMANN LA ROCHE (CH)
HOFFMANN LA ROCHE (CH)
International Classes:
C07K16/28; A61K39/395
Attorney, Agent or Firm:
ZHOU, Jie et al. (US)
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