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Title:
TYROSINE HYDROXYLASE INHIBITORS FOR TREATING INTESTINAL HYPERPERMEABILITY
Document Type and Number:
WIPO Patent Application WO/2015/061328
Kind Code:
A3
Abstract:
The present invention provides methods, compositions, and kits for treating intestinal hyperpermeability in a subject in need thereof, including conditions such as hyperglycemia and underlying diseases such as diabetes, autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease (GVHD), HIV/ AIDS, multiple organ dysfunction syndrome, irritable bowel syndrome (IBS), celiac disease, eczema, psoriasis, acute pancreatitis, Parkinson's disease, depression, chronic fatigue syndrome, asthma, multiple sclerosis, arthritis, ankylosing spondylitis, nonalcoholic fatty liver disease, alcoholic cirrhosis, environmental enteropathy, or kwashiorkor.

Inventors:
HOFFMAN STEVEN (US)
Application Number:
PCT/US2014/061590
Publication Date:
July 23, 2015
Filing Date:
October 21, 2014
Export Citation:
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Assignee:
HOFFMAN STEVEN (US)
International Classes:
A61K31/19; A61K38/34; A61K31/198; A61K31/20; A61K31/216; A61K31/37; A61K31/4166; A61K31/436; A61K31/55; A61K45/06; A61P1/00; A61P1/16; A61P1/18; A61P3/10; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/16; A61P25/24; A61P31/18; A61P37/06; A61P43/00
Foreign References:
US20130243873A12013-09-19
Other References:
See also references of EP 3060241A2
Attorney, Agent or Firm:
LUCCI, Joseph et al. (Cira Centre 12th Floor,2929 Arch Stree, Philadelphia PA, US)
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