Title:
UBIQUITIN-BASED PROTEIN INTERACTION ASSAYS AND RELATED COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2005043170
Kind Code:
A3
Abstract:
The invention provides, inter alia, methods for identifying substrates for E3 proteins that mediate ligation of ubiquitin or ubiquitin-like proteins.
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Inventors:
TUVIA SHMUEL (IL)
TAGLICHT DANIEL N (IL)
TAGLICHT DANIEL N (IL)
Application Number:
PCT/US2004/036455
Publication Date:
August 25, 2005
Filing Date:
November 01, 2004
Export Citation:
Assignee:
PROTEOLOGICS INC (US)
TUVIA SHMUEL (IL)
TAGLICHT DANIEL N (IL)
TUVIA SHMUEL (IL)
TAGLICHT DANIEL N (IL)
International Classes:
C12Q1/37; G01N33/53; G01N33/542; G01N33/68; (IPC1-7): G01N33/68
Domestic Patent References:
| WO2004089302A2 | 2004-10-21 | |||
| WO2004078130A2 | 2004-09-16 | |||
| WO2004098492A2 | 2004-11-18 |
Foreign References:
| EP1310552A2 | 2003-05-14 |
Other References:
BERLETH E S ET AL: "INHIBITION OF UBIQUITIN-PROTEIN LIGASE E3 BY MONO AND BIFUNCTIONAL PHENYLARSENOXIDES EVIDENCE FOR ESSENTIAL VICINAL THIOLS AND A PROXIMAL NUCLEOPHILE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 267, no. 23, 15 August 1992 (1992-08-15), pages 16403 - 16411, XP002316426, ISSN: 0021-9258
AMIT IDO ET AL: "Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding", GENES & DEVELOPMENT, vol. 18, no. 14, 15 July 2004 (2004-07-15), pages 1737 - 1752, XP002330792, ISSN: 0890-9369
NAOMI BISHOP, ALISTAIR HORMAN, AND PHILIP WOODMANN: "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates", THE JOURNAL OF CELL BIOLOGY, vol. 157, no. 1, 1 April 2002 (2002-04-01), pages 91 - 101, XP002330793
CLAUDIA FIGUEROA ET AL: "Akt2 Negatively regulates assembly of the POSH-MLK-JNK Signaling complex", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 48, 28 November 2003 (2003-11-28), pages 47922 - 47927, XP002985545
ZHIHENG XU ET AL: "POSH acts as a scaffold for a multiprotein complex that mediates JNK activatioin in apoptosis", THE EMBO JOURNAL, vol. 22, no. 2, 2003, pages 252 - 261, XP002985544
AMIT IDO ET AL: "Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding", GENES & DEVELOPMENT, vol. 18, no. 14, 15 July 2004 (2004-07-15), pages 1737 - 1752, XP002330792, ISSN: 0890-9369
NAOMI BISHOP, ALISTAIR HORMAN, AND PHILIP WOODMANN: "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates", THE JOURNAL OF CELL BIOLOGY, vol. 157, no. 1, 1 April 2002 (2002-04-01), pages 91 - 101, XP002330793
CLAUDIA FIGUEROA ET AL: "Akt2 Negatively regulates assembly of the POSH-MLK-JNK Signaling complex", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 48, 28 November 2003 (2003-11-28), pages 47922 - 47927, XP002985545
ZHIHENG XU ET AL: "POSH acts as a scaffold for a multiprotein complex that mediates JNK activatioin in apoptosis", THE EMBO JOURNAL, vol. 22, no. 2, 2003, pages 252 - 261, XP002985544
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