Title:
UBIQUITIN LIGASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005007621
Kind Code:
A3
Abstract:
This invention describes compounds useful as ubiquitin ligase inhibitors. The compounds of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also provides for pharmaceutical compositions comprising the compounds described in the invention for the treatment of conditions that require inhibition of ubiquitin ligases. Furthermore, the invention provides for methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound according to the invention.
Inventors:
RAMESH USHA V (US)
LOOK GARY CHARLES (US)
SINGH RAJINDER (US)
ISSAKANI SARKIZ D (US)
LOOK GARY CHARLES (US)
SINGH RAJINDER (US)
ISSAKANI SARKIZ D (US)
Application Number:
PCT/US2004/017380
Publication Date:
April 13, 2006
Filing Date:
June 01, 2004
Export Citation:
Assignee:
RIGEL PHARMACEUTICALS INC (US)
RAMESH USHA V (US)
LOOK GARY CHARLES (US)
SINGH RAJINDER (US)
ISSAKANI SARKIZ D (US)
RAMESH USHA V (US)
LOOK GARY CHARLES (US)
SINGH RAJINDER (US)
ISSAKANI SARKIZ D (US)
International Classes:
C07C233/75; C07C275/34; C07C311/21; C07C311/29; C07C311/48; C07C311/51; C07C311/64; C07C317/34; C07C323/49; C07C335/42; C07D207/16; C07D207/26; C07D207/325; C07D209/08; C07D211/46; C07D211/58; C07D213/42; C07D213/64; C07D213/76; C07D213/78; C07D215/40; C07D217/02; C07D231/56; C07D235/30; C07D239/34; C07D239/42; C07D261/16; C07D265/36; C07D295/13; C07D295/26; C07D307/14; C07D307/91; C07D317/66; C07D319/20; C07D333/36; C07D401/12; C07D207/32; (IPC1-7): C07D295/22; C07D213/78; C07D209/08; C07D213/42; C07D213/76; C07D307/14; C07D207/26; C07D211/58; C07D295/12; C07D207/16; C07D317/66; C07D333/36; C07D231/56; C07D307/91; C07D319/20
Domestic Patent References:
| WO1998045259A2 | 1998-10-15 | |||
| WO1998005315A1 | 1998-02-12 |
Other References:
PEROLA ET AL.: "Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads", J. MED. CHEM., vol. 43, no. 3, 2000, pages 401 - 408, XP002313177
TAMURA Y ET AL: "HIGHLY SELECTIVE AND ORALLY ACTIVE INHIBITORS OF TYPE IV COLLAGENASE (MMP-9 AND MMP-2): N-SULFONYLAMINO ACID DERIVATIVES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 4, 1998, pages 640 - 649, XP002072052, ISSN: 0022-2623
MASTRUKOVA ET AL.: "The application of the Hammett equation to the theory of tautomeric equlibrium - II", TETRAHEDRON, vol. 19, 1963, pages 357 - 372, XP002313178
CHAU ET AL.: "Synthesis of Aromatic Polysulfonamide Esters", JOURNAL OF POLYMER SCIENCE, vol. 18, 1980, pages 3499 - 3503, XP001204312
BADAWI ET AL.: "Uracil, 2,4-Dichlorophenol and Diphenylether Derivatives with antimicrobial Activity", PHARMAZIE, vol. 38, 1983, pages 838 - 841, XP001203948
TAMURA Y ET AL: "HIGHLY SELECTIVE AND ORALLY ACTIVE INHIBITORS OF TYPE IV COLLAGENASE (MMP-9 AND MMP-2): N-SULFONYLAMINO ACID DERIVATIVES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 4, 1998, pages 640 - 649, XP002072052, ISSN: 0022-2623
MASTRUKOVA ET AL.: "The application of the Hammett equation to the theory of tautomeric equlibrium - II", TETRAHEDRON, vol. 19, 1963, pages 357 - 372, XP002313178
CHAU ET AL.: "Synthesis of Aromatic Polysulfonamide Esters", JOURNAL OF POLYMER SCIENCE, vol. 18, 1980, pages 3499 - 3503, XP001204312
BADAWI ET AL.: "Uracil, 2,4-Dichlorophenol and Diphenylether Derivatives with antimicrobial Activity", PHARMAZIE, vol. 38, 1983, pages 838 - 841, XP001203948
Download PDF: