Title:
ULTRA-REMOTE INTELLIGENT DIAGNOSIS AND TREATMENT SYSTEM FOR DIABETES
Document Type and Number:
WIPO Patent Application WO/2018/192156
Kind Code:
A1
Abstract:
An ultra-remote intelligent diagnosis and treatment system for diabetes comprises an in-vivo implantable LED and a hydrogel transplant carrier containing a photo-controlled engineered cell, which is formed from a hydrogel-coated engineered cell regulated and expressed by far-red light and secreting insulin or glucagon-like peptide, and a far-infrared LED. A far-red light-regulated gene expression loop control system comprising a photoreceptor to receive a far-red light source, a processor to process a signal transmitted by the photoreceptor, and an effector to respond to the signal transmitted by the processor is further provided. The far-red light-regulated gene expression loop control system controls the level of gene expression through the far-red light-regulated gene expression. The system can convert a blood glucose concentration signal into an optical signal or control command of a user's mobile phone to control an optical module implanted in-vivo to precisely regulate the expression level of insulin or glucagon-like peptide, thereby achieving a goal of an automatic, precise, and individualized treatment of diabetes.
Inventors:
YE HAIFENG (CN)
SHAO JIAWEI (CN)
YU GUILING (CN)
XUE SHUAI (CN)
YU YUANHUAN (CN)
BAI YU (CN)
SHAO JIAWEI (CN)
YU GUILING (CN)
XUE SHUAI (CN)
YU YUANHUAN (CN)
BAI YU (CN)
Application Number:
PCT/CN2017/100448
Publication Date:
October 25, 2018
Filing Date:
September 05, 2017
Export Citation:
Assignee:
SUZHOU SYNTHERAPY CO LTD (CN)
International Classes:
C12M1/42; A61K48/00; A61P3/10; C12M1/36; C12N13/00; C12N15/85
Foreign References:
| CN107177498A | 2017-09-19 | |||
| CN104323781A | 2015-02-04 | |||
| CN1914823A | 2007-02-14 | |||
| CN101365381A | 2009-02-11 |
Other References:
SHAO, J. W.: "Smartphone-controlled optogenetically engineered cells ena- ble semiautomatic glucose homeostasis in diabetic mice", SCIENCE TRANSLATIONAL MEDICINE, vol. 9, no. 387, 26 April 2017 (2017-04-26), XP055613568
RYU, M. H.: "Near-infrared Light Responsive Synthetic c-di-GMP Module for Optogenetic Applications", ACS SYNTHETIC BIOLOGY, vol. 3, no. 11, 8 December 2014 (2014-12-08), pages 802 - 810, XP002734154
RYU, M. H.: "Near-infrared Light Responsive Synthetic c-di-GMP Module for Optogenetic Application", ACS SYNTHETIC BIOLOGY, vol. 3, 8 December 2014 (2014-12-08), pages 802 - 810, XP002734154
YE, H. F.: "A Synthetic Optogenetic Transcription Device Enhances Blood- Glucose Homeostasis in Mice", SCIENCE, vol. 332, no. 6037, 24 June 2011 (2011-06-24), pages 1565 - 8, XP002699843
WALTZ, E.: "Drugs go wireless", NATURE BIOTECHNOLOGY, vol. 34, 31 January 2016 (2016-01-31), pages 15 - 18, XP055613580
TOPOL, E. J.: "Transforming Medicine via Digital Innovation", SCIENCE TRANSLATIONAL MEDICINE, vol. 2, no. 16, 27 January 2010 (2010-01-27), pages 1 - 4, XP055613582
RYU, M. H.: "Near-infrared Light Responsive Synthetic c-di-GMP Module for Optogenetic Applications", ACS SYNTHETIC BIOLOGY, vol. 3, no. 11, 8 December 2014 (2014-12-08), pages 802 - 810, XP002734154
RYU, M. H.: "Near-infrared Light Responsive Synthetic c-di-GMP Module for Optogenetic Application", ACS SYNTHETIC BIOLOGY, vol. 3, 8 December 2014 (2014-12-08), pages 802 - 810, XP002734154
YE, H. F.: "A Synthetic Optogenetic Transcription Device Enhances Blood- Glucose Homeostasis in Mice", SCIENCE, vol. 332, no. 6037, 24 June 2011 (2011-06-24), pages 1565 - 8, XP002699843
WALTZ, E.: "Drugs go wireless", NATURE BIOTECHNOLOGY, vol. 34, 31 January 2016 (2016-01-31), pages 15 - 18, XP055613580
TOPOL, E. J.: "Transforming Medicine via Digital Innovation", SCIENCE TRANSLATIONAL MEDICINE, vol. 2, no. 16, 27 January 2010 (2010-01-27), pages 1 - 4, XP055613582
Attorney, Agent or Firm:
MSJ LAW OFFICE (CN)
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