Title:
ULTRAFINE IRON OXIDE NANOPARTICLE-BASED MAGNETIC RESONANCE IMAGING T1 CONTRAST AGENT
Document Type and Number:
WIPO Patent Application WO/2020/197046
Kind Code:
A1
Abstract:
Provided is a magnetic resonance imaging T1 contrast agent comprising: a fine iron oxide nanoparticle core; and a micelle for encapsulating the core particles, wherein the micelle comprises a non-ionic surfactant containing: a hydrophilic residue containing at least two chains; and a hydrophobic residue consisting of at least one C10-C30 hydrocarbon chain. The magnetic resonance imaging T1 contrast agent of the present invention is a novel fine iron oxide nanoparticle-based T1 contrast agent that can replace conventional gadolinium-based T1 contrast agents, is not harmful to the human body due to being based on iron oxide nanoparticles, and exhibits a uniform contrast effect due to rapid distribution in blood and the uniform size. In addition, the contrast agent enables image observation for 1 hour or longer, or up to a maximum of 2 hours or longer and is excreted through the kidneys and liver, and thus can address the problems of conventional gadolinium-based contrast agents.
Inventors:
LEE YUN SANG (KR)
HYEON TAEG HWAN (KR)
JEONG JAE MIN (KR)
LEE JAE SUNG (KR)
PARK JI YONG (KR)
KIM KYU WAN (KR)
SHIN JAE HWAN (KR)
KO GUEN BAE (KR)
LEE WHAL (KR)
PARK EUN AH (KR)
HYEON TAEG HWAN (KR)
JEONG JAE MIN (KR)
LEE JAE SUNG (KR)
PARK JI YONG (KR)
KIM KYU WAN (KR)
SHIN JAE HWAN (KR)
KO GUEN BAE (KR)
LEE WHAL (KR)
PARK EUN AH (KR)
Application Number:
PCT/KR2019/017870
Publication Date:
October 01, 2020
Filing Date:
December 17, 2019
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
SEOUL NAT UNIV HOSPITAL (KR)
INST BASIC SCIENCE (KR)
SEOUL NAT UNIV HOSPITAL (KR)
INST BASIC SCIENCE (KR)
International Classes:
A61K49/18
Domestic Patent References:
| WO2015140160A1 | 2015-09-24 |
Foreign References:
| KR101416290B1 | 2014-07-09 | |||
| KR20130113575A | 2013-10-16 | |||
| KR20120021249A | 2012-03-08 | |||
| KR102026100B1 | 2019-09-27 |
Other References:
WU, H.: "Water-soluble nanocrystals through dual-interaction ligands", ANGEW. CHEM. INT. ED, vol. 120, no. 20, 9 April 2008 (2008-04-09), pages 3730 - 3734, XP055841563
See also references of EP 3922271A4
See also references of EP 3922271A4
Attorney, Agent or Firm:
KWAK, Hyun Kyu (KR)
Download PDF: