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Title:
ULTRALONG COMPLEMENTARITY DETERMINING REGIONS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/106485
Kind Code:
A3
Abstract:
Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity- determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.

Inventors:
BAZIRGAN OMAR A (US)
MAO HONGYUAN HELEN (US)
SMIDER VAUGHN (US)
EKIERT DAN (US)
SCHULTZ PETER (US)
WANG FENG (US)
WILSON IAN (US)
ZHANG YONG (US)
Application Number:
PCT/US2013/020903
Publication Date:
March 06, 2014
Filing Date:
January 09, 2013
Export Citation:
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Assignee:
SCRIPPS RESEARCH INST (US)
BAZIRGAN OMAR A (US)
MAO HONGYUAN HELEN (US)
International Classes:
C07K16/18; A61K39/395; A61P35/00; C12N15/13; C12N15/63; C40B40/08; C40B40/10
Domestic Patent References:
WO2010028791A12010-03-18
Foreign References:
US20030170646A12003-09-11
US20110172125A12011-07-14
US20030088074A12003-05-08
Other References:
SAINI. SURINDER S. ET AL.: "Exceptionally long CDR3H region with multiple cysteine residues in functional bovine IgM antibodies", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 29, no. 8, 5 August 1999 (1999-08-05), pages 2420 - 2426, XP055158026
Attorney, Agent or Firm:
HARDT, Ingo, H. (650 Page Mill RoadPalo Alto, CA, US)
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