Title:
ULTRASOUND IMAGE-BASED CONCENTRATION MEASUREMENT
Document Type and Number:
WIPO Patent Application WO/2016/210246
Kind Code:
A3
Abstract:
The systems and methods of the present disclosure are directed to ultrasound- based concentration measurement techniques in which both scatterer count and image volume are measured concurrently to provide absolute concentration measurements. In particular, through the techniques of the present disclosure, the effective thickness of an ultrasound beam can be determined based on the spreading of individual scatterers within ultrasound images. Based on the effective thickness of the ultrasound beam, the volume of the image and, thus, the concentration of particles in the image can be determined directly, without the need for estimation, approximation, or use of a reference sample.
Inventors:
LEE JOHN HAESEON (US)
ANTHONY BRIAN W (US)
BONING DUANE S (US)
ANTHONY BRIAN W (US)
BONING DUANE S (US)
Application Number:
PCT/US2016/039210
Publication Date:
March 09, 2017
Filing Date:
June 24, 2016
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
G01N15/06; A61B8/14; G01N29/032; G01N29/06; G01N29/44; G01N33/543; G01N15/00; G01N15/10
Foreign References:
| US20120227473A1 | 2012-09-13 | |||
| US20050150275A1 | 2005-07-14 |
Other References:
DAVID P HRUSKA ET AL: "Improved parameter estimates based on the homodyned K distribution", IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS AND FREQUENCY CONTROL, IEEE, US, vol. 56, no. 11, 1 November 2009 (2009-11-01), pages 2471 - 2481, XP011279125, ISSN: 0885-3010, DOI: 10.1109/TUFFC.2009.1334
KARLA P MERCADO ET AL: "Estimating Cell Concentration in Three-Dimensional Engineered Tissues Using High Frequency Quantitative Ultrasound", ANNALS OF BIOMEDICAL ENGINEERING, 1 June 2014 (2014-06-01), Boston, pages 1292 - 1304, XP055298810, Retrieved from the Internet [retrieved on 20160831], DOI: 10.1007/s10439-014-0994-8
LEE JOHN H ET AL: "Ultrasound image-based absolute concentration measurement technique for materials with low scatterer concentration", 2015 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), IEEE, 21 October 2015 (2015-10-21), pages 1 - 4, XP032799235, DOI: 10.1109/ULTSYM.2015.0208
KARLA P MERCADO ET AL: "Estimating Cell Concentration in Three-Dimensional Engineered Tissues Using High Frequency Quantitative Ultrasound", ANNALS OF BIOMEDICAL ENGINEERING, 1 June 2014 (2014-06-01), Boston, pages 1292 - 1304, XP055298810, Retrieved from the Internet
LEE JOHN H ET AL: "Ultrasound image-based absolute concentration measurement technique for materials with low scatterer concentration", 2015 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), IEEE, 21 October 2015 (2015-10-21), pages 1 - 4, XP032799235, DOI: 10.1109/ULTSYM.2015.0208
Attorney, Agent or Firm:
MAZZARESE, Robert, A. et al. (US)
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