Title:
UNAGGLOMERATED DISSOLVING COMPOSITION FOR DIAGNOSIS OF ALZHEIMER'S DISEASE OR MILD COGNITIVE IMPAIRMENT, AND DIAGNOSTIC METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/200281
Kind Code:
A1
Abstract:
The present invention relates to an unagglomerated dissolving composition for the diagnosis of Alzheimer's disease or mild cognitive impairment, and a diagnostic method using same, wherein the present invention is useful in tracking pathological changes through the measurement of total-tau, phosphorylated tau, and beta-amyloid in plasma of Alzheimer's disease patients. In particular, it is possible to measure total-tau, phosphorylated tau, and beta-amyloid in blood without additionally requiring expensive special equipment and by using commonly used antibodies and equipment without additional processing for amyloid antibodies. In addition, the present invention enables the analysis of changes in representative proteins of Alzheimer's disease through a buffer treatment-concentration-lipase treatment presented in the present invention by using blood plasma itself, without a specially processed treatment step for amyloid-specific antibodies. Therefore, the composition and diagnostic method of the present invention have high diagnostic accuracy and reproducibility, and are also very simple so as to be able to be very effectively used for early diagnosis of Alzheimer's disease.
Inventors:
CHOE YOUNGSHIK (KR)
YEO SEUNGEUN (KR)
LEE SANGKYU (KR)
JANG JAEMYUNG (KR)
JUNG HYUN-JIN (KR)
YEO SEUNGEUN (KR)
LEE SANGKYU (KR)
JANG JAEMYUNG (KR)
JUNG HYUN-JIN (KR)
Application Number:
PCT/KR2023/005049
Publication Date:
October 19, 2023
Filing Date:
April 14, 2023
Export Citation:
Assignee:
DAEGU GYEONGBUK INST SCIENCE & TECH (KR)
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
UNIV CHOSUN IACF (KR)
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
UNIV CHOSUN IACF (KR)
International Classes:
G01N1/40; C07K1/12; C07K1/30; C07K1/34; C07K14/47; G01N33/68
Foreign References:
| KR20150008309A | 2015-01-22 | |||
| JP6308393B2 | 2018-04-11 | |||
| KR102313791B1 | 2021-10-19 | |||
| KR20150058292A | 2015-05-28 | |||
| EP2318035B1 | 2019-06-12 |
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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