Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
UNDIFFERENTIATED CELL DETECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2019/240247
Kind Code:
A1
Abstract:
Provided is a marker gene capable of detecting the persistence/admixture of undifferentiated cells in a differentiated cell population. Undifferentiated cells present in a differentiated cell population are detected by using at least one gene selected from the group consisting of ESRG, VSNL1, THY1, SFRP2, SPP1, USP44, and CNMD as an undifferentiation marker. A method for detecting undifferentiated cells, a method of use as an undifferentiation marker, and an undifferentiated cell detection kit. Also provided is a method for selecting an undifferentiated cell line.

Inventors:
TANIGUCHI HIDEKI (JP)
SEKINE KEISUKE (JP)
Application Number:
JP2019/023599
Publication Date:
December 19, 2019
Filing Date:
June 14, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
International Classes:
C12Q1/04; C12Q1/6834; C12Q1/6837; C12Q1/6841; C12Q1/686; C12Q1/6869; C12Q1/6881; C12Q1/6897; G01N33/50; G01N33/53; G01N33/68; C12N15/09
Foreign References:
KR20120114084A2012-10-16
Other References:
TANG, CHAD ET AL.: "An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells", NATURE BIOTECHNOLOGY, vol. 29, no. 9, 14 August 2011 (2011-08-14), pages 829 - 834, XP055067218, DOI: 10.1038/nbt.1947
HAMADA, YUKI, ET. AL.: "Establishment of safety evaluation method for clinical application of human iPSC liver bud", 17TH CONGRESS OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, 23 February 2018 (2018-02-23), pages 644, XP055663130, Retrieved from the Internet [retrieved on 20190522]
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
Download PDF: