Title:
UNIVERSAL CHIMERIC ANTIGEN RECEPTOR T-CELL PREPARATION TECHNIQUE
Document Type and Number:
WIPO Patent Application WO/2019/047899
Kind Code:
A1
Abstract:
Provided are a universal chimeric antigen receptor (CAR) T-cell and preparation method and application thereof. The binding of the cell HLA-A/HLA-B to the TCR is inhibited; the TCR gene expression is silenced; the invention may be used for allogeneic tumor treatment and does not cause GVHD and HVG reaction during allogeneic infusion, and thus improves the survival and antineoplastic effect of allogeneic CAR T-cells in the receptor.
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Inventors:
SHI ZHONGDONG (CN)
LIU LIPING (CN)
YANG CHUNHUI (CN)
SUN JING (CN)
CAI SONGBAI (CN)
CAO WEI (CN)
LIU LIPING (CN)
YANG CHUNHUI (CN)
SUN JING (CN)
CAI SONGBAI (CN)
CAO WEI (CN)
Application Number:
PCT/CN2018/104418
Publication Date:
March 14, 2019
Filing Date:
September 06, 2018
Export Citation:
Assignee:
GRACELL BIOTECHNOLOGIES SHANGHAI CO LTD (CN)
International Classes:
C12N5/10
Domestic Patent References:
| WO2016069282A1 | 2016-05-06 | |||
| WO2013074916A1 | 2013-05-23 | |||
| WO2001096584A2 | 2001-12-20 | |||
| WO2001029058A1 | 2001-04-26 |
Foreign References:
| US5399346A | 1995-03-21 | |||
| US5580859A | 1996-12-03 | |||
| US5589466A | 1996-12-31 | |||
| US6326193B1 | 2001-12-04 | |||
| US5350674A | 1994-09-27 | |||
| US5585362A | 1996-12-17 |
Other References:
TORIKAI, H. ET AL.: "Toward Eliminating HLA Class I Expression to Generate Universal Cell : from Allogeneic Donors", BLOOD, vol. 122, no. 8, 5 June 2013 (2013-06-05), XP002719612, ISSN: 1528-0020
LIU, X. ET AL.: "CRISPR-Cas9-Mediated Muyltiplex Gene Editing in CAR-T cells", CELL RES., vol. 27, no. 1, 2 December 2016 (2016-12-02), XP055555205, ISSN: 1748-7838
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY
UI-TEI ET AL., FEBS LETTERS, vol. 479, 2000, pages 79 - 82
ROSENBERG ET AL., NEW ENG. J. OF MED., vol. 319, 1988, pages 1676
GONZALEZZHUSHI ET AL., CELL STEM CELL, 2014
See also references of EP 3680328A4
LIU, X. ET AL.: "CRISPR-Cas9-Mediated Muyltiplex Gene Editing in CAR-T cells", CELL RES., vol. 27, no. 1, 2 December 2016 (2016-12-02), XP055555205, ISSN: 1748-7838
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY
UI-TEI ET AL., FEBS LETTERS, vol. 479, 2000, pages 79 - 82
ROSENBERG ET AL., NEW ENG. J. OF MED., vol. 319, 1988, pages 1676
GONZALEZZHUSHI ET AL., CELL STEM CELL, 2014
See also references of EP 3680328A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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