a, ß-UNSATURATED ESTERS AND ACIDS BY STEREOSELECTIVE DEHYDRATION

Title:

a, ß-UNSATURATED ESTERS AND ACIDS BY STEREOSELECTIVE DEHYDRATION

Document Type and Number:

WIPO Patent Application WO2006004742

Kind Code:

A3

Abstract:

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R¹, R², R³, R⁴ and R⁵ are certain organic substituents, methods for making the same, and stereoselective dehydration methods for generally making a,ß-unsaturated esters, acids and their derivatives.

Inventors:

DENG XIAOHU (US)
MANI NEELAKANDHA (US)
MAPES CHRISTOPHER M (US)

Application Number:

PCT/US2005/022910

Publication Date:

December 07, 2006

Filing Date:

June 28, 2005

Export Citation:

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Assignee:

JANSSEN PHARAMCEUTICA N V (BE)
DENG XIAOHU (US)
MANI NEELAKANDHA (US)
MAPES CHRISTOPHER M (US)

International Classes:

C07D231/12

Foreign References:

US5051518A

1991-09-24

Other References: