Title:
URACIL DERIVATIVE HAVING VIRAL GROWTH INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2023/195530
Kind Code:
A1
Abstract:
The present invention provides a compound showing coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. A compound represented by formula (I) [in the formula: ring A is a ring represented by formula (I-A) (wherein X is a single bond, etc., R2 is a substituted or unsubstituted aromatic carbocyclic group, etc., and R3c is a substituted or unsubstituted aromatic carbocyclic group, etc.); R1 is a substituted or unsubstituted aromatic heterocyclic group; m is 0, etc.; R5as are independently a hydrogen atom, etc.; R5bs are independently a hydrogen atom, etc.; R6 is cyano, etc.; and R7a and R7b are independently a hydrogen atom, etc.], or a pharmaceutically acceptable salt thereof.
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Inventors:
SATO JUN (JP)
SHIBAYAMA HIROMITSU (JP)
HIRAI KEIICHIRO (JP)
UNOH YUTO (JP)
UEHARA SHOTA (JP)
YONEZAWA SHUJI (JP)
KURAHASHI KANA (JP)
KOJIMA EIICHI (JP)
SHIBAYAMA HIROMITSU (JP)
HIRAI KEIICHIRO (JP)
UNOH YUTO (JP)
UEHARA SHOTA (JP)
YONEZAWA SHUJI (JP)
KURAHASHI KANA (JP)
KOJIMA EIICHI (JP)
Application Number:
PCT/JP2023/014318
Publication Date:
October 12, 2023
Filing Date:
April 07, 2023
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D401/04; A61K31/506; A61P31/14; A61P43/00; C07D401/14; C07D471/04; C07D491/107; C12N7/06; C12N9/99; C12Q1/37
Domestic Patent References:
| WO2012020742A1 | 2012-02-16 | |||
| WO2013118855A1 | 2013-08-15 | |||
| WO2021250648A1 | 2021-12-16 |
Foreign References:
| CN113620888A | 2021-11-09 | |||
| CN113666914A | 2021-11-19 | |||
| CN113735838A | 2021-12-03 | |||
| CN113801097A | 2021-12-17 |
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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