Title:
URACIL DERIVATIVES AS INHIBITORS OF TNF-ALPHA CONVERTING ENZYME (TACE) AND MATRIX METALLOPROTEINASES
Document Type and Number:
WIPO Patent Application WO2003079986
Kind Code:
A3
Abstract:
The present application describes novel uracil derivatives of formula I: A-W-U-X-Y-Z-U-X-Y-Z or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, W, U, X, Y, Z, U, X, Y, and Z are defined in the present specification, which are useful as inhibitors of TNF-alpha converting enzyme (TACE), matrix metalloproteinases (MMP), aggrecanase or a combination thereof.
Inventors:
MADUSKUIE THOMAS P (US)
Application Number:
PCT/US2003/008412
Publication Date:
May 13, 2004
Filing Date:
March 14, 2003
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
MADUSKUIE THOMAS P (US)
MADUSKUIE THOMAS P (US)
International Classes:
A61P25/00; C07D239/545; C07D239/69; C07D401/12; C07D239/54; (IPC1-7): A61K31/505; A61P25/00; C07D239/02; C07D401/00; C07D403/00
Domestic Patent References:
| WO2001074753A1 | 2001-10-11 |
Foreign References:
| US3242180A | 1966-03-22 | |||
| US4722929A | 1988-02-02 | |||
| US5591776A | 1997-01-07 |
Download PDF: