Title:
KIDNEY−SPECIFIC URATE TRANSPORTER AND GENE THEREOF
Document Type and Number:
WIPO Patent Application WO/2003/027287
Kind Code:
A1
Abstract:
It is intended to identify and provide a novel urate transporter gene participating in the urate transport in the kidney and a urate transporter which is a polypeptide encoded by the above gene. Namely, a protein comprising the amino aid sequence represented by SEQ ID NO:1 or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids and being capable of transporting uric acid and its analogs&semi and a gene encoding this protein.
Inventors:
ENDOU HITOSHI (JP)
KANAI YOSHIKATSU (JP)
ENOMOTO ATSUSHI (JP)
KANAI YOSHIKATSU (JP)
ENOMOTO ATSUSHI (JP)
Application Number:
PCT/JP2002/008457
Publication Date:
April 03, 2003
Filing Date:
August 22, 2002
Export Citation:
Assignee:
ENDOU HITOSHI (JP)
KANAI YOSHIKATSU (JP)
ENOMOTO ATSUSHI (JP)
KANAI YOSHIKATSU (JP)
ENOMOTO ATSUSHI (JP)
International Classes:
G01N33/50; A61K38/00; A61K39/395; A61K45/00; A61P19/06; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12Q1/68; G01N33/15; (IPC1-7): C12N15/12; C12P21/02; C07K14/47; C12Q1/68
Other References:
LIPKOWITZ MICHAEL S. ET AL.: "Functional reconstitution, membrane targeting, genomic structure and chromosomal localization of a human urate transporter", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 107, no. 9, May 2001 (2001-05-01), pages 1103 - 1115, XP002182345
RACE JOANNE E. ET AL.: "Molecular cloning and characterization of two novel human renal organic anion teansporters (hOAT1 and hOAT3)", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 255, no. 2, 1999, pages 508 - 514, XP002124962
DATABASE GENBANK [online] 21 January 2001 (2001-01-21), "NIH-MGC 602107541F1 NCI CGAP Kid14 Mus usculus cDNA clone IMAGE:4235795 5', mRNA sequence", XP002961054, Database accession no. (BF782700)
RACE JOANNE E. ET AL.: "Molecular cloning and characterization of two novel human renal organic anion teansporters (hOAT1 and hOAT3)", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 255, no. 2, 1999, pages 508 - 514, XP002124962
DATABASE GENBANK [online] 21 January 2001 (2001-01-21), "NIH-MGC 602107541F1 NCI CGAP Kid14 Mus usculus cDNA clone IMAGE:4235795 5', mRNA sequence", XP002961054, Database accession no. (BF782700)
Attorney, Agent or Firm:
Saeki, Norio (Taka-ai Building 15-2, Nihonbashi 3-chom, Chuo-ku Tokyo, JP)
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