Title:
UREA COMPOUND AS DUAL INHIBITOR OF IDO AND TDO
Document Type and Number:
WIPO Patent Application WO/2018/171602
Kind Code:
A1
Abstract:
Provided are a urea compound having a dual inhibitory activity against IDO and TDO and being represented by the formula (I) or a pharmaceutically acceptable salt thereof, a preparation method and pharmaceutical composition thereof, and a use of the same in treating an immunosuppressive disease mediated by IDO or TDO.
Inventors:
WANG DAKE (CN)
ZHANG YINGLI (CN)
WANG SHULONG (CN)
MIN WANGYANG (CN)
CHEN KUNCHENG (CN)
LIU ZHIHUA (CN)
LIU XIJIE (CN)
HU YUANDONG (CN)
ZHAO NA (CN)
PENG YONG (CN)
LUO HONG (CN)
TIAN XIN (CN)
ZHANG XIQUAN (CN)
ZHANG YINGLI (CN)
WANG SHULONG (CN)
MIN WANGYANG (CN)
CHEN KUNCHENG (CN)
LIU ZHIHUA (CN)
LIU XIJIE (CN)
HU YUANDONG (CN)
ZHAO NA (CN)
PENG YONG (CN)
LUO HONG (CN)
TIAN XIN (CN)
ZHANG XIQUAN (CN)
Application Number:
PCT/CN2018/079718
Publication Date:
September 27, 2018
Filing Date:
March 21, 2018
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO LTD (CN)
CENTAURUS BIOPHARMA CO LTD (CN)
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO LTD (CN)
CENTAURUS BIOPHARMA CO LTD (CN)
International Classes:
C07D487/04; A61K31/381; A61K31/41; A61P31/00; A61P35/00; A61P37/00; C07D231/56; C07D471/04; C07D471/14
Domestic Patent References:
| WO2018036414A1 | 2018-03-01 |
Foreign References:
| CN105884780A | 2016-08-24 | |||
| CN106478634A | 2017-03-08 | |||
| CN107033087A | 2017-08-11 |
Other References:
PAWAR C.D.: "Synthesis and Antimicrobial Evaluation of Novel Substituted Acetamido-4-subtituted-thiazole-5-indazole Derivatives", RESEARCH & REVIEWS: JOURNAL OF CHEMISTRY, vol. 5, 2 September 2016 (2016-09-02), pages 3, XP055540615, ISSN: 2319-9849
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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