Title:
UREA COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/121560
Kind Code:
A1
Abstract:
The present invention relates to a urea compound and a preparation method and an application thereof. The structure of the present compound is represented by formula (I), the definition of each variable in the formula being as described in the description. The compound can block interaction between the PD-1/PD-L1 signalling pathways. The compound of the present invention can be used for treating or preventing diseases related to the signalling pathways, such as cancer, autoimmune disease, chronic infectious disease, and other diseases.
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Inventors:
YANG QIANJIAO (CN)
LU XIANPING (CN)
LI ZHIBIN (CN)
XIN LIJUN (CN)
SONG YONGLIAN (CN)
FU CHAO (CN)
LU XIANPING (CN)
LI ZHIBIN (CN)
XIN LIJUN (CN)
SONG YONGLIAN (CN)
FU CHAO (CN)
Application Number:
PCT/CN2017/118844
Publication Date:
July 05, 2018
Filing Date:
December 27, 2017
Export Citation:
Assignee:
SHENZHEN CHIPSCREEN BIOSCIENCES LTD (CN)
International Classes:
C07D405/14; A61K31/165; A61K31/357; A61K31/40; A61K31/505; A61K45/06; A61P35/00; C07D215/16; C07D217/02; C07D233/36; C07D249/08
Domestic Patent References:
| WO2015160641A2 | 2015-10-22 | |||
| WO2015057250A1 | 2015-04-23 |
Foreign References:
| CN105705489A | 2016-06-22 | |||
| CN201611245660A | 2016-12-29 |
Other References:
AHMAD, MD. FAIZ ET AL.: "Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 24, 21 October 2015 (2015-10-21), pages 9498 - 9508, XP055511580, Retrieved from the Internet
COUZIN-FRANKEL J., SCIENCE, vol. 342, 2013, pages 1432 - 1433
SHARMA P.ALLISON J.P., SCIENCE, vol. 348, 2015, pages 56 - 61
MELLMAN I.COUKOS G.DRANOFF G., NATURE, vol. 480, 2011, pages 480 - 489
PARDOLL D.M., NAT. REV. CANCER., vol. 12, 2012, pages 252 - 264
CHENG X.VEVERKA V.RADHAKRISHNAN A. ET AL., J. BIOL. CHEM., vol. 288, 2013, pages 11771 - 11785
LAZAR-MOLNAR E.YAN Q.CAO E. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 105, 2008, pages 10483 - 10488
GHIOTTO M.GAUTHIER L.SERRIARI N. ET AL., INT. IMMUNOL., vol. 22, 2010, pages 651 - 660
FULLER M.J.CALLENDRET B.ZHU B. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 110, 2013, pages 15001 - 15006
DOLAN D.E.GUPTA S., CANCER CONTROL, vol. 21, 2014, pages 231 - 237
CHEN L.HAN X., J. CLIN. INVEST., vol. 125, 2015, pages 3384 - 3391
POSTOW M.A.CALLAHAN M.K.WOLCHOK J.D., J. CLIN. ONCOL., vol. 33, 2015, pages 1974 - 1982
LI Y.LI F.JIANG F. ET AL., INT. J. MOL. SCI., vol. 17, 2016, pages E1151
See also references of EP 3564237A4
COUZIN-FRANKEL J., SCIENCE, vol. 342, 2013, pages 1432 - 1433
SHARMA P.ALLISON J.P., SCIENCE, vol. 348, 2015, pages 56 - 61
MELLMAN I.COUKOS G.DRANOFF G., NATURE, vol. 480, 2011, pages 480 - 489
PARDOLL D.M., NAT. REV. CANCER., vol. 12, 2012, pages 252 - 264
CHENG X.VEVERKA V.RADHAKRISHNAN A. ET AL., J. BIOL. CHEM., vol. 288, 2013, pages 11771 - 11785
LAZAR-MOLNAR E.YAN Q.CAO E. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 105, 2008, pages 10483 - 10488
GHIOTTO M.GAUTHIER L.SERRIARI N. ET AL., INT. IMMUNOL., vol. 22, 2010, pages 651 - 660
FULLER M.J.CALLENDRET B.ZHU B. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 110, 2013, pages 15001 - 15006
DOLAN D.E.GUPTA S., CANCER CONTROL, vol. 21, 2014, pages 231 - 237
CHEN L.HAN X., J. CLIN. INVEST., vol. 125, 2015, pages 3384 - 3391
POSTOW M.A.CALLAHAN M.K.WOLCHOK J.D., J. CLIN. ONCOL., vol. 33, 2015, pages 1974 - 1982
LI Y.LI F.JIANG F. ET AL., INT. J. MOL. SCI., vol. 17, 2016, pages E1151
See also references of EP 3564237A4
Attorney, Agent or Firm:
SHENPAT INTELLECTUAL PROPERTY AGENCY (CN)
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