Title:
UREA-COMPOUNDS ACTIVE AS VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN
Document Type and Number:
WIPO Patent Application WO2003022809
Kind Code:
A3
Abstract:
Certain compounds of formula (I): or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein R1, R2, P, P', n, p, q, r and s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and composition for the treatment of disorders relating to the vanilloid receptor (VR1) such as pain, migraine, neuropathy, ischaemia, neurodegeneration, stroke, multiple sclerosis, asthma, inflammatory diseases.
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Inventors:
RAMI HARSHAD KANTILAL (GB)
THOMPSON MERVYN (GB)
WYMAN PAUL ADRIAN (GB)
THOMPSON MERVYN (GB)
WYMAN PAUL ADRIAN (GB)
Application Number:
PCT/GB2002/004206
Publication Date:
July 17, 2003
Filing Date:
September 13, 2002
Export Citation:
Assignee:
SMITHKLINE BEECHAM PLC (GB)
RAMI HARSHAD KANTILAL (GB)
THOMPSON MERVYN (GB)
WYMAN PAUL ADRIAN (GB)
RAMI HARSHAD KANTILAL (GB)
THOMPSON MERVYN (GB)
WYMAN PAUL ADRIAN (GB)
International Classes:
A61K31/443; A61K31/4725; A61P9/10; A61P25/00; A61P25/04; A61P29/00; A61P43/00; C07D401/04; C07D401/12; C07D401/14; (IPC1-7): C07D401/04; C07D401/14; C07D401/12; A61K31/4025; A61K31/4709; A61K31/4725; A61P25/00; A61P9/10
Domestic Patent References:
| WO2002090326A1 | 2002-11-14 | |||
| WO2001028987A1 | 2001-04-26 | |||
| WO1999000128A1 | 1999-01-07 | |||
| WO1999000121A1 | 1999-01-07 | |||
| WO1992019618A1 | 1992-11-12 |
Foreign References:
| US3424760A | 1969-01-28 | |||
| US3424761A | 1969-01-28 | |||
| EP0790240A1 | 1997-08-20 | |||
| US4001422A | 1977-01-04 |
Other References:
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TANIGUCHI, NOBUAKI ET AL: "Preparation of heterocyclic moiety-containing benzonitrile derivatives as antiandrogen agents", XP002225002, retrieved from STN Database accession no. 136:279475
PAN P-C ET AL: "Soluble Polymer-Supported Synthesis of Arylpiperazines", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 51, 17 December 1998 (1998-12-17), pages 9505 - 9508, XP004144238, ISSN: 0040-4039
HELSLEY G C ET AL: "SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 1-SUBSITUTED 3-PYRROLIDINYLUREAS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 11, no. 5, September 1968 (1968-09-01), pages 1034 - 1037, XP001095126, ISSN: 0022-2623
MASTERS, JOHN J. ET AL: "Non-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potent Anticoagulant and Antithrombotic Activity", JOURNAL OF MEDICINAL CHEMISTRY (2000), 43(11), 2087-2092, XP002238143
PAN P-C ET AL: "Soluble Polymer-Supported Synthesis of Arylpiperazines", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 51, 17 December 1998 (1998-12-17), pages 9505 - 9508, XP004144238, ISSN: 0040-4039
HELSLEY G C ET AL: "SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 1-SUBSITUTED 3-PYRROLIDINYLUREAS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 11, no. 5, September 1968 (1968-09-01), pages 1034 - 1037, XP001095126, ISSN: 0022-2623
MASTERS, JOHN J. ET AL: "Non-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potent Anticoagulant and Antithrombotic Activity", JOURNAL OF MEDICINAL CHEMISTRY (2000), 43(11), 2087-2092, XP002238143
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