UREA DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINE CONTAINING THE UREA DERIVATIVE

Title:

UREA DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINE CONTAINING THE UREA DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2001/032610

Kind Code:

A1

Abstract:

A urea derivative represented by the general formula (I) or a salt thereof: wherein R?1¿ is hydrogen, alkyl, etc.; X is hydrogen, halogeno, alkyl, aryl, arylamide, etc.; Y is oxygen or sulfur; and Z is a hydrocarbon or heterocyclic group containing a nitrogen atom through which Z is bonded to the carbon atom of C=Y. The urea derivative or salt thereof is a novel compound having VLA-4 antagonistic activity, and is useful in a medicine as a VLA-4 antagonist.

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Inventors:

OKUYAMA AKIHIKO (JP)
IKEGAMI SATORU (JP)
HARADA TATSUHIRO (JP)
MARUYAMA TATSUYA (JP)
MATSUMURA YUZURU (JP)
NAGATA NAOYA (JP)
FUKUI HIDETO (JP)
FUJIMOTO KYOUKO (JP)

Application Number:

PCT/JP2000/007571

Publication Date:

May 10, 2001

Filing Date:

October 27, 2000

Export Citation:

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Assignee:

KAKEN PHARMA CO LTD (JP)
OKUYAMA AKIHIKO (JP)
IKEGAMI SATORU (JP)
HARADA TATSUHIRO (JP)
MARUYAMA TATSUYA (JP)
MATSUMURA YUZURU (JP)
NAGATA NAOYA (JP)
FUKUI HIDETO (JP)
FUJIMOTO KYOUKO (JP)

International Classes:

C07C275/24; C07C275/26; C07C275/42; C07C335/14; C07C335/16; C07C335/22; (IPC1-7): C07C275/24; A61K31/198; A61K31/341; A61K31/381; A61K31/40; A61K31/403; A61K31/4035; A61K31/426; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/47; A61K31/472; A61K31/4965; A61K31/498; A61K31/538; A61K31/55; A61P1/04; A61P3/10; A61P9/10; A61P11/06; A61P13/12; A61P19/02; A61P21/00; A61P29/00; A61P35/00; A61P37/06; A61P37/08; C07C275/26; C07C275/42; C07C335/12; C07C335/14; C07C335/22; C07D207/06; C07D209/08; C07D209/94; C07D211/14; C07D211/16; C07D213/40; C07D215/08; C07D217/06; C07D223/16; C07D241/12; C07D241/40; C07D265/36; C07D277/28; C07D307/52; C07D333/20; C07D333/52; C07D333/58

Domestic Patent References:

WO1999020272A1	1999-04-29
WO1997036859A1	1997-10-09

Foreign References:

JPH072843A	1995-01-06
JPH06184086A	1994-07-05

Attorney, Agent or Firm:

Nakamura, Shizuo (ST Bldg. 24-10 Taito 2-chome Taito-ku, Tokyo, JP)

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