Title:
UREA DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/066646
Kind Code:
A1
Abstract:
The present invention addresses the problem of finding a novel medicine which has an excellent tryptophanase inhibitory effect, suppresses indoxyl sulfate production in blood to thereby prevent deterioration of renal function, and thus contributes to kidney preservation. Provided is a medicinal composition which comprises a compound represented by the formula or a pharmacologically acceptable salt thereof as an active ingredient. (In the formula: R1 and R2 may be the same or different and represent a C1-C6 alkyl group, etc.; and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.)
Inventors:
SONEDA TSUYOSHI (JP)
NAKAMURA YUJI (JP)
MATSUMOTO KOJI (JP)
TANAKA NAOMI (JP)
FUKUNAGA TAICHI (JP)
NAKAMURA YUJI (JP)
MATSUMOTO KOJI (JP)
TANAKA NAOMI (JP)
FUKUNAGA TAICHI (JP)
Application Number:
PCT/JP2017/036272
Publication Date:
April 12, 2018
Filing Date:
October 05, 2017
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K31/198; A61K31/381; A61K31/40; A61K31/4453; A61P13/12; A61P43/00; C07C275/28; C07C275/30; C07C275/34; C07C275/42; C07C323/44; C07D207/10; C07D295/135; C07D333/36
Domestic Patent References:
| WO2014138037A1 | 2014-09-12 | |||
| WO2013070600A1 | 2013-05-16 | |||
| WO2014146995A1 | 2014-09-25 |
Foreign References:
| JP2015502924A | 2015-01-29 | |||
| JPH11209303A | 1999-08-03 | |||
| JP2016069495A | 2016-05-09 | |||
| JPS58188864A | 1983-11-04 |
Other References:
KOZO YAMADA ET AL.: "beta-Phenyl Isopropyl Hydrzine no Vitamin B6 Koso Sogai", FOLIA ENDOCRINOLOGICA JAPONICA, vol. 37, no. 10, 1961, pages 1068 - 1072, XP055597328, DOI: 10.1507/endocrine1927.37.10_1068
SCHULMAN-G, AJKD, vol. 47, no. 4, 2006
SHIMIZU-H, AM J PHYSIOL CELL PHYSIOL, vol. 299, 2010, pages C1110 - C1117
ICHII-O, PLOS ONE, vol. 9, no. 9, 2014, pages e108448
"Bunshi Sekkei (Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN CO., article "Iyakuhin no Kaihatsu (Development of Pharmaceuticals", pages: 163 - 198
P. G. M. WUTST. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
TETRAHEDRON: ASYMMETRY, vol. 18, 2007, pages 569 - 623
"4th series of experimental chemistry", vol. 20, 22, CHEMICAL SOCIETY OF JAPAN
J. JACQUES: "Enantiomers, Racemates and Resolution", JOHN WILEY AND SONS, INC.
ELLIS-RJ, NEPHROLOGY, vol. 21, 2016, pages 170 - 177
HAYEK-SS, N ENGL J MED, vol. 373, 2015, pages 1916 - 1925
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 2566-29-2
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 35037-73-1
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 5687-72-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1003865-65-3
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 141345-74-6
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, 1992, pages 4095 - 4106
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 3059-97-0
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1548-13-6
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 6321-21-7
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 103-71-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1864016-20-5
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1195-45-5
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 404-71-7
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 104-12-1
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 2909-38-8
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1413936-87-4
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 8, 2012, pages 1265 - 1270
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 24065-33-6
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 102-36-3
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 2493-02-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 15845-62-2
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1261862-00-3
ACS CHEMICAL NEUROSCIENCE, vol. 4, 2013, pages 1217 - 1228
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1261672-37-0
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 59513-89-2
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 92-95-5
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 70974-26-4
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1993-03-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 163457-23-6
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1028206-60-1
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 787618-22-8
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 595-40-4
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 58417-15-5
PHILLIPS-RS ET AL., BIOCHEMISTRY, vol. 23, 1984, pages 6228 - 6234
"Genbank", Database accession no. HC914434.1
See also references of EP 3524240A4
SCHULMAN-G, AJKD, vol. 47, no. 4, 2006
SHIMIZU-H, AM J PHYSIOL CELL PHYSIOL, vol. 299, 2010, pages C1110 - C1117
ICHII-O, PLOS ONE, vol. 9, no. 9, 2014, pages e108448
"Bunshi Sekkei (Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN CO., article "Iyakuhin no Kaihatsu (Development of Pharmaceuticals", pages: 163 - 198
P. G. M. WUTST. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
TETRAHEDRON: ASYMMETRY, vol. 18, 2007, pages 569 - 623
"4th series of experimental chemistry", vol. 20, 22, CHEMICAL SOCIETY OF JAPAN
J. JACQUES: "Enantiomers, Racemates and Resolution", JOHN WILEY AND SONS, INC.
ELLIS-RJ, NEPHROLOGY, vol. 21, 2016, pages 170 - 177
HAYEK-SS, N ENGL J MED, vol. 373, 2015, pages 1916 - 1925
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 2566-29-2
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 35037-73-1
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 5687-72-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1003865-65-3
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 141345-74-6
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, 1992, pages 4095 - 4106
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 3059-97-0
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1548-13-6
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 6321-21-7
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 103-71-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1864016-20-5
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1195-45-5
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 404-71-7
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 104-12-1
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 2909-38-8
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1413936-87-4
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 8, 2012, pages 1265 - 1270
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 24065-33-6
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 102-36-3
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 2493-02-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 15845-62-2
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1261862-00-3
ACS CHEMICAL NEUROSCIENCE, vol. 4, 2013, pages 1217 - 1228
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1261672-37-0
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 59513-89-2
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 92-95-5
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 70974-26-4
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1993-03-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 163457-23-6
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1028206-60-1
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 787618-22-8
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 595-40-4
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 58417-15-5
PHILLIPS-RS ET AL., BIOCHEMISTRY, vol. 23, 1984, pages 6228 - 6234
"Genbank", Database accession no. HC914434.1
See also references of EP 3524240A4
Attorney, Agent or Firm:
ISHIBASHI, Koki et al. (JP)
Download PDF:
Previous Patent: CELL EXTERIOR MEMBER LAMINATE SHEET
Next Patent: SYNCHRONOUS RELUCTANCE TYPE ROTARY ELECTRIC MACHINE
Next Patent: SYNCHRONOUS RELUCTANCE TYPE ROTARY ELECTRIC MACHINE