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Title:
UREA DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/066646
Kind Code:
A1
Abstract:
The present invention addresses the problem of finding a novel medicine which has an excellent tryptophanase inhibitory effect, suppresses indoxyl sulfate production in blood to thereby prevent deterioration of renal function, and thus contributes to kidney preservation. Provided is a medicinal composition which comprises a compound represented by the formula or a pharmacologically acceptable salt thereof as an active ingredient. (In the formula: R1 and R2 may be the same or different and represent a C1-C6 alkyl group, etc.; and Ar represents an optionally substituted phenyl group or an optionally substituted thienyl group.)

Inventors:
SONEDA, Tsuyoshi (LIMITED 3-5-1,Nihonbashi Honcho,Chuo-k, Tokyo 26, 〒1038426, JP)
NAKAMURA, Yuji (LIMITED 3-5-1,Nihonbashi Honcho,Chuo-k, Tokyo 26, 〒1038426, JP)
MATSUMOTO, Koji (LIMITED 3-5-1,Nihonbashi Honcho,Chuo-k, Tokyo 26, 〒1038426, JP)
TANAKA, Naomi (LIMITED 3-5-1,Nihonbashi Honcho,Chuo-k, Tokyo 26, 〒1038426, JP)
FUKUNAGA, Taichi (LIMITED 3-5-1,Nihonbashi Honcho,Chuo-k, Tokyo 26, 〒1038426, JP)
Application Number:
JP2017/036272
Publication Date:
April 12, 2018
Filing Date:
October 05, 2017
Export Citation:
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Assignee:
DAIICHI SANKYO COMPANY,LIMITED (3-5-1, Nihonbashi HonchoChuo-k, Tokyo 26, 〒1038426, JP)
International Classes:
A61K31/198; A61K31/381; A61K31/40; A61K31/4453; A61P13/12; A61P43/00; C07C275/28; C07C275/30; C07C275/34; C07C275/42; C07C323/44; C07D207/10; C07D295/135; C07D333/36
Domestic Patent References:
WO2014138037A12014-09-12
WO2013070600A12013-05-16
WO2014146995A12014-09-25
Foreign References:
JP2015502924A2015-01-29
JPH11209303A1999-08-03
JP2016069495A2016-05-09
JPS58188864A1983-11-04
Other References:
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"Genbank", Database accession no. HC914434.1
Attorney, Agent or Firm:
ISHIBASHI, Koki et al. (LIMITED 1-2-58, Hiromach, Shinagawa-ku Tokyo 05, 〒1400005, JP)
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