Title:
UREA DERIVATIVES HAVING VANILLOID RECEPTOR ANTAGONIST ACTIVITY
Document Type and Number:
WIPO Patent Application WO2004078101
Kind Code:
A3
Abstract:
According to the invention there are provided compounds of formula (I) wherein R1, p, P, n, s, r, W, P', t, R2 and q are as defined in the specification, processes for preparing them and their use in therapy.
Inventors:
MACDONALD GREGOR JAMES (GB)
RAMI HARSHAD KANTILAL (GB)
THOMPSON MERVYN (GB)
RAMI HARSHAD KANTILAL (GB)
THOMPSON MERVYN (GB)
Application Number:
PCT/EP2004/002376
Publication Date:
February 17, 2005
Filing Date:
March 04, 2004
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
MACDONALD GREGOR JAMES (GB)
RAMI HARSHAD KANTILAL (GB)
THOMPSON MERVYN (GB)
MACDONALD GREGOR JAMES (GB)
RAMI HARSHAD KANTILAL (GB)
THOMPSON MERVYN (GB)
International Classes:
C07D401/12; C07D401/14; (IPC1-7): C07D401/12; A61K31/404; A61K31/4725; C07D401/14
Domestic Patent References:
| WO2004024710A1 | 2004-03-25 | |||
| WO2004026836A2 | 2004-04-01 | |||
| WO2003070242A1 | 2003-08-28 | |||
| WO2003022809A2 | 2003-03-20 | |||
| WO2003072545A1 | 2003-09-04 | |||
| WO2001014333A1 | 2001-03-01 | |||
| WO1997038984A1 | 1997-10-23 | |||
| WO2000021952A1 | 2000-04-20 | |||
| WO2000071171A2 | 2000-11-30 | |||
| WO2001007409A1 | 2001-02-01 | |||
| WO2001057008A1 | 2001-08-09 |
Foreign References:
| DE19955794A1 | 2000-05-31 | |||
| EP0416581A1 | 1991-03-13 | |||
| EP0628310A1 | 1994-12-14 | |||
| DE2816884A1 | 1978-11-02 |
Other References:
CARLING R W ET AL: "1-(3-CYANOBENZYLPIPERIDIN-4-YL)-5-METHYL-4-PHENYL-1,3-DIHYDROIMIDAZOL 2-ONE: A SELECTIVE HIGH-AFFINITY ANTAGONISTS FOR THE HUMAN DOPAMINE D4 RECEPTOR WITH EXCELLENT SELECTIVITY OVER ION CHANNELS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 14, 1999, pages 2706 - 2715, XP001093697, ISSN: 0022-2623
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ORJALES VENERO, AURELIO ET AL: "Preparation of new antihistaminic 4-piperidinealkylurea derivatives", XP002300376, retrieved from STN Database accession no. 1991:143155
HUANG, YUNSHENG ET AL: "Synthesis and Quantitative Structure-Activity Relationships of N-(1-Benzylpiperidin-4-yl)phenylacetamides and Related Analogs as Potent and Selective .sigma.1 Receptor Ligands", JOURNAL OF MEDICINAL CHEMISTRY , 41(13), 2361-2370 CODEN: JMCMAR; ISSN: 0022-2623, 1998, XP002154246
HUANG, YUNSHENG ET AL: "Synthesis and Structure-Activity Relationships of N-(1-Benzylpiperidin-4- yl)arylacetamide Analogues as Potent .sigma.1 Receptor Ligands", JOURNAL OF MEDICINAL CHEMISTRY , 44(25), 4404-4415 CODEN: JMCMAR; ISSN: 0022-2623, 2001, XP002300374
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ORJALES VENERO, AURELIO ET AL: "Preparation of new antihistaminic 4-piperidinealkylurea derivatives", XP002300376, retrieved from STN Database accession no. 1991:143155
HUANG, YUNSHENG ET AL: "Synthesis and Quantitative Structure-Activity Relationships of N-(1-Benzylpiperidin-4-yl)phenylacetamides and Related Analogs as Potent and Selective .sigma.1 Receptor Ligands", JOURNAL OF MEDICINAL CHEMISTRY , 41(13), 2361-2370 CODEN: JMCMAR; ISSN: 0022-2623, 1998, XP002154246
HUANG, YUNSHENG ET AL: "Synthesis and Structure-Activity Relationships of N-(1-Benzylpiperidin-4- yl)arylacetamide Analogues as Potent .sigma.1 Receptor Ligands", JOURNAL OF MEDICINAL CHEMISTRY , 44(25), 4404-4415 CODEN: JMCMAR; ISSN: 0022-2623, 2001, XP002300374
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