Title:
UREA DERIVATIVES FOR USE AGAINST PROLIFERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO/2020/126968
Kind Code:
A3
Abstract:
The present invention covers urea compounds of general formula (I) in which R1, A and B are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
Inventors:
BRÄUER NICO (DE)
EHRMANN ALEXANDER (US)
GORJANACZ MATYAS (DE)
STRESEMANN CARLO (DE)
EHRMANN ALEXANDER (US)
GORJANACZ MATYAS (DE)
STRESEMANN CARLO (DE)
Application Number:
PCT/EP2019/085239
Publication Date:
July 30, 2020
Filing Date:
December 16, 2019
Export Citation:
Assignee:
BAYER AG (DE)
International Classes:
A61P35/00; A61K31/437; A61K31/44; A61K31/443; A61K31/4439; A61K31/4545; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; C07D213/75; C07D213/84; C07D401/12; C07D401/14; C07D405/12; C07D413/12; C07D417/12; C07D471/04
Domestic Patent References:
| WO2012103523A2 | 2012-08-02 | |||
| WO2006018662A2 | 2006-02-23 | |||
| WO1984003884A1 | 1984-10-11 |
Foreign References:
| EP1256574A1 | 2002-11-13 | |||
| US4193788A | 1980-03-18 | |||
| US4279639A | 1981-07-21 | |||
| US4308054A | 1981-12-29 | |||
| ES2201909A1 | 2004-03-16 | |||
| ES2209622A1 | 2004-06-16 |
Other References:
SHAN YUANYUAN ET AL: "Expanding the structural diversity of diarylureas as multi-target tyrosine kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY : A TETRAHEDRON PUBLICATION FOR THE RAPID DISSEMINATION OF FULL ORIGINAL RESEARCH PAPERS AND CRITICAL REVIEWS ON BIOMOLECULAR CHEMISTRY, MEDICINAL CHEMISTRY AND RELATED DISCIPLINES, ELSEVIER, NL, vol. 24, no. 4, 23 December 2015 (2015-12-23), pages 750 - 758, XP029399995, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2015.12.038
ZHONG-WEI HOU ET AL: "Electrochemical C-H/N-H Functionalization for the Synthesis of Highly Functionalized (Aza)indoles", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 55, no. 32, 1 August 2016 (2016-08-01), DE, pages 9168 - 9172, XP055671001, ISSN: 1433-7851, DOI: 10.1002/anie.201602616
TOSHIHIKO OKAMOTO ET AL: "4-Pyridylureas are surprisingly potent cytokinins. The structure-activity relationship.", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 29, no. 12, 1 January 1981 (1981-01-01), JP, pages 3748 - 3750, XP055670855, ISSN: 0009-2363, DOI: 10.1248/cpb.29.3748
KOPECNY D ET AL: "Phenyl- and benzylurea cytokinins as competitive inhibitors of cytokinin oxidase/dehydrogenase: A structural study", BIOCHIMIE, MASSON, PARIS, FR, vol. 92, no. 8, 1 August 2010 (2010-08-01), pages 1052 - 1062, XP027141295, ISSN: 0300-9084, [retrieved on 20100515]
JULIEN P. N. PAPILLON ET AL: "Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, no. 22, 19 October 2018 (2018-10-19), US, pages 10155 - 10172, XP055619669, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01318
ZHONG-WEI HOU ET AL: "Electrochemical C-H/N-H Functionalization for the Synthesis of Highly Functionalized (Aza)indoles", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 55, no. 32, 1 August 2016 (2016-08-01), DE, pages 9168 - 9172, XP055671001, ISSN: 1433-7851, DOI: 10.1002/anie.201602616
TOSHIHIKO OKAMOTO ET AL: "4-Pyridylureas are surprisingly potent cytokinins. The structure-activity relationship.", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 29, no. 12, 1 January 1981 (1981-01-01), JP, pages 3748 - 3750, XP055670855, ISSN: 0009-2363, DOI: 10.1248/cpb.29.3748
KOPECNY D ET AL: "Phenyl- and benzylurea cytokinins as competitive inhibitors of cytokinin oxidase/dehydrogenase: A structural study", BIOCHIMIE, MASSON, PARIS, FR, vol. 92, no. 8, 1 August 2010 (2010-08-01), pages 1052 - 1062, XP027141295, ISSN: 0300-9084, [retrieved on 20100515]
JULIEN P. N. PAPILLON ET AL: "Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, no. 22, 19 October 2018 (2018-10-19), US, pages 10155 - 10172, XP055619669, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01318
Attorney, Agent or Firm:
BIP PATENTS (DE)
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