Title:
UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/154132
Kind Code:
A1
Abstract:
The present invention relates to an urea-substituted aromatic ring-linked dioxazoline compound of formula (I), a pharmaceutically acceptable salt or hydrate thereof. The invention also provides a preparation method of the compound of formula (I) and a pharmaceutically acceptable salt thereof, as well as uses thereof as a drug, wherein the drug acting as a tyrosine kinase (i.e. VEGFR -2, C-RAF, B-RAF, and RET) inhibitor is used for treating disorders related to tyrosine kinase.
Inventors:
ZHANG QIANG (CN)
YU SHANNAN (CN)
WANG ZHONGXIANG (CN)
FENG SHOUYE (CN)
LIU YANSHENG (CN)
LI XINGFU (CN)
ZHANG HONGBO (CN)
YANG LEIFU (CN)
YANG HAILONG (CN)
ZHOU LIKAI (CN)
ZHENG NANQIAO (CN)
HU CHENMING (CN)
XU ZHANQIANG (CN)
YU SHANNAN (CN)
WANG ZHONGXIANG (CN)
FENG SHOUYE (CN)
LIU YANSHENG (CN)
LI XINGFU (CN)
ZHANG HONGBO (CN)
YANG LEIFU (CN)
YANG HAILONG (CN)
ZHOU LIKAI (CN)
ZHENG NANQIAO (CN)
HU CHENMING (CN)
XU ZHANQIANG (CN)
Application Number:
PCT/CN2019/073259
Publication Date:
August 15, 2019
Filing Date:
January 25, 2019
Export Citation:
Assignee:
BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN)
International Classes:
C07D491/056; A61K31/519; A61K31/5377; A61P35/00
Domestic Patent References:
| WO2018157730A1 | 2018-09-07 |
Foreign References:
| CN104530063A | 2015-04-22 | |||
| CN105837586A | 2016-08-10 | |||
| CN201810160412A | 2018-02-26 |
Other References:
"Handbook of Pharmaceutical Excipients", AMERICAN PHARMACEUTICAL ASSOCIATION AND THE PHARMACEUTICAL SOCIETY OF GREAT BRITAIN
See also references of EP 3750894A4
See also references of EP 3750894A4
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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