UREIDIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND THEIR USE ON THE TREATMENT OF INFLAMMATORY DISEASES

WIPO Patent Application WO2006128268

A8

The present invention describes functionalizeds derivatives of ethyl 6-N- alkyl and/or 6-N-aryl ureas [1 ,3]dioxolo[5,4-g]quinolin-7-carboxylate (3a-z, 4a-z) and similar types (5a-z), of general formula (I, II, III and IV), useful in the treatment and/or prevention of inflammatory diseases, such as acute or chronic inflammatory conditions, different types of arthritis, asthma, Crohn's Disease and diabetes mellitus Type I, among others. These derivatives have the ability of modulate the inflammatory process, acting in mitogen activated protein kinase p-38 (MAPK-p38). Moreover, the derivatives of the present invention present expressive anti-inflammatory properties evaluated in in vivo models. The present invention also discloses processes for the production of such derivatives and harmaceutical com ositions containin the same.

LACERDA BARREIRO ELIEZER JESUS (BR)
MANSSOUR FRAGA CARLOS ALBERTO (BR)
SPERANDIO DA SILVA GILBERTO MA (BR)
MOREIRA LIMA LIDIA (BR)
MEDEIROS DE CARVALHO FATIMA (BR)
MENEZES QUINTAS LUIS EDUARDO
LEGORA MACHADO ALEXANDRE
GONCALVES KOATZ VERA LUCIA

PCT/BR2006/000107

April 26, 2007

June 01, 2006

Click for automatic bibliography generation  

UNIV RIO DE JANEIRO (BR)
LACERDA BARREIRO ELIEZER JESUS (BR)
MANSSOUR FRAGA CARLOS ALBERTO (BR)
SPERANDIO DA SILVA GILBERTO MA (BR)
MOREIRA LIMA LIDIA (BR)
MEDEIROS DE CARVALHO FATIMA (BR)
MENEZES QUINTAS LUIS EDUARDO
LEGORA MACHADO ALEXANDRE
GONCALVES KOATZ VERA LUCIA

C07D491/056; C07D491/14; A61K31/4741; A61P29/00; C07C275/38

View/Download PDF      PDF Help

Previous Patent: PHARMACEUTICAL COMPOSITIONS OF THE PEPTIDE ANGIOTENSIN-(1 -7) [ANG-(I -7)] AND ITS ANALOGUES, AGONIS...

Next Patent: PRODUCTS FOR TONGUE CLEANING AND FOR PREVENTING AND TREATING HALITOSIS AND EQUIPMENT FOR TONGUE CLEA...