Title:
URICASE-ALBUMIN CONJUGATE DERIVED FROM ARTHROBACTER GLOBIFORMIS, METHOD FOR PRODUCING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/282556
Kind Code:
A1
Abstract:
The present specification discloses: a uricase-albumin conjugate and a method for producing same; and a uricase variant included in the uricase-albumin conjugate and a method for producing same. In particular, the present specification discloses a uricase variant derived from Arthrobacter globiformis. The uricase-albumin conjugate is characterized by conjugation of three or more albumins to a uricase variant via linkers, and accordingly exhibits the effects of improving the half-life and reducing immunogenicity. In addition, the uricase-albumin conjugate can be used for the prevention or treatment of various diseases, disorders and/or indications that are caused by uric acid.
Inventors:
KWON INCHAN (KR)
YANG BYUNGSEOP (KR)
YANG BYUNGSEOP (KR)
Application Number:
PCT/KR2022/009593
Publication Date:
January 12, 2023
Filing Date:
July 04, 2022
Export Citation:
Assignee:
PROABTECH CO LTD (KR)
International Classes:
A61K38/44; C07C255/50; A61K47/64; A61P19/06; C07K14/195; C07K14/76; C07K14/765; C12N9/06
Domestic Patent References:
| WO2022065913A1 | 2022-03-31 |
Foreign References:
| KR20180002828A | 2018-01-08 | |||
| US20200010450A1 | 2020-01-09 |
Other References:
YANG BYUNGSEOP, KWON INCHAN: "Multivalent Albumin–Neonatal Fc Receptor Interactions Mediate a Prominent Extension of the Serum Half-Life of a Therapeutic Protein", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 18, no. 6, 7 June 2021 (2021-06-07), US , pages 2397 - 2405, XP093021165, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.1c00231
DATABASE NUCLEOTIDE 5 November 2005 (2005-11-05), ANONYMOUS : "Arthrobacter globiformis gene for uricase,complete cds", XP093021168, retrieved from NCBI Database accession no. E13225.1
YANG BYUNGSEOP, KWON KIYOON, JANA SUBHASHIS, KIM SEOUNGKYUN, AVILA-CRUMP SAVANNA, TAE GIYOONG, MEHL RYAN A., KWON INCHAN: "Temporal Control of Efficient In Vivo Bioconjugation Using a Genetically Encoded Tetrazine-Mediated Inverse-Electron-Demand Diels–Alder Reaction", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 10, 21 October 2020 (2020-10-21), US , pages 2456 - 2464, XP055966436, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00497
DATABASE NUCLEOTIDE 5 November 2005 (2005-11-05), ANONYMOUS : "Arthrobacter globiformis gene for uricase,complete cds", XP093021168, retrieved from NCBI Database accession no. E13225.1
YANG BYUNGSEOP, KWON KIYOON, JANA SUBHASHIS, KIM SEOUNGKYUN, AVILA-CRUMP SAVANNA, TAE GIYOONG, MEHL RYAN A., KWON INCHAN: "Temporal Control of Efficient In Vivo Bioconjugation Using a Genetically Encoded Tetrazine-Mediated Inverse-Electron-Demand Diels–Alder Reaction", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 31, no. 10, 21 October 2020 (2020-10-21), US , pages 2456 - 2464, XP055966436, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00497
Attorney, Agent or Firm:
IPLAY PATENT LAW FIRM (KR)
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