Title:
URICOSURIC AGENT, SYNTHETIC METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/083182
Kind Code:
A1
Abstract:
A compound of a uricosuric agent used as a uric acid transporter (URAT1) inhibitor, and application thereof in preparation of a medication for treating a disease related to abnormal uric acid levels. The present invention specifically relates to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
Inventors:
WANG JIANFEI (CN)
ZHANG YANG (CN)
ZHU WENYUAN (CN)
LI JIAN (CN)
CHEN SHUHUI (CN)
ZHANG YANG (CN)
ZHU WENYUAN (CN)
LI JIAN (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2020/124298
Publication Date:
May 06, 2021
Filing Date:
October 28, 2020
Export Citation:
Assignee:
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D277/02; A61K31/426; A61K31/427; A61P19/06; C07D277/18; C07D413/00; C07D417/00
Domestic Patent References:
| WO2007122241A1 | 2007-11-01 |
Foreign References:
| CN108721283A | 2018-11-02 | |||
| JPS62123180A | 1987-06-04 | |||
| CN102007123A | 2011-04-06 |
Other References:
JUNSHENG ZHU, LE HAN, YANYAN DIAO, XIAOLI REN, MINGHAO XU, LIUXIN XU, SHILIANG LI, QIANG LI, DONG DONG, JIN HUANG, XIAOFENG LIU, Z: "Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase,", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 3, 12 January 2015 (2015-01-12), pages 1123 - 1139, XP055333919, ISSN: 0022-2623, DOI: 10.1021/jm501127s
ZHU JUNSHENG ET AL.,: "Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase,", J. MED. CHEM.,, vol. 58,, 12 January 2015 (2015-01-12)
KAMELIA M AMIN , DOAA E ABDEL RAHMAN , YASMIN A AL-ERYANI: "Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 10, 2008515, pages 5377 - 5388, XP022673120, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2008.04.021
NICOLAS DESROY, ALEXIS DENIS, CHRYSTELLE OLIVEIRA, DMYTRO ATAMANYUK, SOPHIA BRIET, FABIEN FAIVRE, GÉRALDINE LEFRALLIEC, YANNICK BO: "Novel HldE-K Inhibitors Leading to Attenuated Gram Negative Bacterial Virulence,", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 4, 28 February 2013 (2013-02-28), pages 1418 - 1430, XP055706248, ISSN: 0022-2623, DOI: 10.1021/jm301499r
DATABASE REGISTRY 14 June 2015 (2015-06-14), ANONYMOUS: "- 5-Oxazolecarboxylic acid, 2-[(phenylamino)methyl]- (CA INDEX NAME)", XP055806946, retrieved from STN Database accession no. 1779910-75-6
DATABASE REGISTRY 19 April 2011 (2011-04-19), ANONYMOUS: "-5-Thiazolecarboxylic acid, 2-[[(2,3-dihydro-1,4-benzodioxin-6- yl)amino]methyl]-4-methyl- (CA INDEX NAME)", XP055806948, retrieved from STN Database accession no. 1282168-24-4
CHOE JUNG-YOON; KIM SEONG-KYU: "Association between serum uric acid and inflammation in rheumatoid arthritis: Perspective on lowering serum uric acid of leflunomide,", CLINICA CHIMICA ACTA, vol. 438, 7 August 2014 (2014-08-07), pages 29 - 34, XP029020349, ISSN: 0009-8981, DOI: 10.1016/j.cca.2014.07.039
ALMEER RAFA S., HAMMAD SHERIF F., LEHETA OLA F., ABDEL MONEIM AHMED E., AMIN HATEM K.: "Anti-Inflammatory and Anti-Hyperuricemic Functions of Two Synthetic Hybrid Drugs with Dual Biological Active Sites,", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, no. 22, 5635, 11 November 2019 (2019-11-11), pages 1 - 13, XP055804504, ISSN: 1422-0067, DOI: 10.3390/ijms20225635
ZHU JUNSHENG ET AL.,: "Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase,", J. MED. CHEM.,, vol. 58,, 12 January 2015 (2015-01-12)
KAMELIA M AMIN , DOAA E ABDEL RAHMAN , YASMIN A AL-ERYANI: "Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 10, 2008515, pages 5377 - 5388, XP022673120, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2008.04.021
NICOLAS DESROY, ALEXIS DENIS, CHRYSTELLE OLIVEIRA, DMYTRO ATAMANYUK, SOPHIA BRIET, FABIEN FAIVRE, GÉRALDINE LEFRALLIEC, YANNICK BO: "Novel HldE-K Inhibitors Leading to Attenuated Gram Negative Bacterial Virulence,", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 4, 28 February 2013 (2013-02-28), pages 1418 - 1430, XP055706248, ISSN: 0022-2623, DOI: 10.1021/jm301499r
DATABASE REGISTRY 14 June 2015 (2015-06-14), ANONYMOUS: "- 5-Oxazolecarboxylic acid, 2-[(phenylamino)methyl]- (CA INDEX NAME)", XP055806946, retrieved from STN Database accession no. 1779910-75-6
DATABASE REGISTRY 19 April 2011 (2011-04-19), ANONYMOUS: "-5-Thiazolecarboxylic acid, 2-[[(2,3-dihydro-1,4-benzodioxin-6- yl)amino]methyl]-4-methyl- (CA INDEX NAME)", XP055806948, retrieved from STN Database accession no. 1282168-24-4
CHOE JUNG-YOON; KIM SEONG-KYU: "Association between serum uric acid and inflammation in rheumatoid arthritis: Perspective on lowering serum uric acid of leflunomide,", CLINICA CHIMICA ACTA, vol. 438, 7 August 2014 (2014-08-07), pages 29 - 34, XP029020349, ISSN: 0009-8981, DOI: 10.1016/j.cca.2014.07.039
ALMEER RAFA S., HAMMAD SHERIF F., LEHETA OLA F., ABDEL MONEIM AHMED E., AMIN HATEM K.: "Anti-Inflammatory and Anti-Hyperuricemic Functions of Two Synthetic Hybrid Drugs with Dual Biological Active Sites,", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, no. 22, 5635, 11 November 2019 (2019-11-11), pages 1 - 13, XP055804504, ISSN: 1422-0067, DOI: 10.3390/ijms20225635
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
Download PDF: