Title:
UROKINASE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1984/004536
Kind Code:
A1
Abstract:
The urokinase derivatives are either urokinase bound covalently with fibrinogen, or urokinase which is covalently bound through aliphatic diamine with fibrinogen, and represented by general formula (I), wherein P is fibrinogen, E is urokinase and R either is not present at all or defines the group (II), where n = 1-12, the molecular mass of the urokinase derivatives being in an amount of 360000 to 440000 D, the content of protein therein amounts to 10-30 % by mass and the esterase catalytic activity thereof is in the range of 30 to 60 %. Said derivatives possess an enhanced affinity to fibrine and have a prolonged fabrinolytic effect.
Inventors:
MAXIMENKO ALEXANDR VASILIEVICH (SU)
TISCHENKO ELENA GEORGIEVNA (SU)
TORCHILIN VLADIMIR PETROVICH (SU)
SMIRNOV VLADIMIR NIKOLAEVICH (SU)
CHAZOV EVGENY IVANOVICH (SU)
TISCHENKO ELENA GEORGIEVNA (SU)
TORCHILIN VLADIMIR PETROVICH (SU)
SMIRNOV VLADIMIR NIKOLAEVICH (SU)
CHAZOV EVGENY IVANOVICH (SU)
Application Number:
PCT/SU1984/000008
Publication Date:
November 22, 1984
Filing Date:
March 01, 1984
Export Citation:
Assignee:
VSESOJUZNYJ KARDIOLOGITSCHES (SU)
International Classes:
A61K38/00; A61K38/46; A61K47/48; A61K38/49; A61P7/02; C12N9/72; C12N9/96; C12N11/00; C12N11/02; (IPC1-7): C12N9/72; C12N11/02; A61K37/48
Foreign References:
| US4349630A | 1982-09-14 | |||
| JPS54113488A | 1979-09-05 |
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