Title:
UROKINASE PEPTIDE STRUCTURE MIMETICS
Document Type and Number:
WIPO Patent Application WO2002016929
Kind Code:
A3
Abstract:
The NMR structure of the peptidic urokinase type plasminogen activator antagonist cyclo[21,29][D-Cys21Cys29]-uPA21-30 has been solved to identify design strategies for peptidomimetics that interfere with the binding of urokinase type plasminogen activator with its receptor.
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Inventors:
WILHELM OLAF (DE)
BUERGLE MARKUS (DE)
KESSLER HORST (DE)
SCHMIEDEBERG NIKO (DE)
BUERGLE MARKUS (DE)
KESSLER HORST (DE)
SCHMIEDEBERG NIKO (DE)
Application Number:
PCT/EP2001/009668
Publication Date:
October 10, 2002
Filing Date:
August 21, 2001
Export Citation:
Assignee:
WILEX AG (DE)
WILHELM OLAF (DE)
BUERGLE MARKUS (DE)
KESSLER HORST (DE)
SCHMIEDEBERG NIKO (DE)
WILHELM OLAF (DE)
BUERGLE MARKUS (DE)
KESSLER HORST (DE)
SCHMIEDEBERG NIKO (DE)
International Classes:
C12N9/72; G01N33/573; (IPC1-7): G01N33/573; C12N9/72
Domestic Patent References:
| WO1998046632A2 | 1998-10-22 | |||
| WO1998021230A1 | 1998-05-22 | |||
| WO2001005811A2 | 2001-01-25 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MAGDOLEN, VIKTOR ET AL: "Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87)", XP002207722, retrieved from STN Database accession no. 136:112295 CA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BURGLE, MARKUS ET AL: "Inhibition of the interaction of urokinase-type plasminogen activator (uPA) with its receptor (uPAR) by synthetic peptides", XP002207723, retrieved from STN Database accession no. 127:77905 CA
ZESLAWSKA, EWA ET AL: "Crystals of the Urokinase Type Plasminogen Activator Variant.beta.c-uPA in Complex with Small Molecule Inhibitors Open the Way towards Structure-based Drug Design", JOURNAL OF MOLECULAR BIOLOGY (2000), 301(2), 465-475, 11 August 2000 (2000-08-11), XP002207720
NIENABER, VICKI L. ET AL: "Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite", STRUCTURE (LONDON) (2000), 8(5), 553-563, 3 May 2000 (2000-05-03), XP002207721
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BURGLE, MARKUS ET AL: "Inhibition of the interaction of urokinase-type plasminogen activator (uPA) with its receptor (uPAR) by synthetic peptides", XP002207723, retrieved from STN Database accession no. 127:77905 CA
ZESLAWSKA, EWA ET AL: "Crystals of the Urokinase Type Plasminogen Activator Variant.beta.c-uPA in Complex with Small Molecule Inhibitors Open the Way towards Structure-based Drug Design", JOURNAL OF MOLECULAR BIOLOGY (2000), 301(2), 465-475, 11 August 2000 (2000-08-11), XP002207720
NIENABER, VICKI L. ET AL: "Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite", STRUCTURE (LONDON) (2000), 8(5), 553-563, 3 May 2000 (2000-05-03), XP002207721
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